Evaluation of physical and chemical stability of semi-solid preparations towards beyond-use date

Abstract

Background: Semi-solid formulations require careful consideration due to potential drug interactions and incompatibilities. The stability of these compounds is crucial for determining the quality of a preparation, often assessed by its designated shelf life.

Objective: This research synthesizes previous studies to provide a comprehensive assessment of the quality and stability of semi-solid drugs, focusing on evaluating their physical and chemical stability in relation to the Beyond Use Date (BUD).

Methods: A literature review was conducted using the Google Scholar database, yielding eight articles that met the established inclusion and exclusion criteria and were pertinent to the research topic.

Results: The evaluations of physical stability indicated that preparations are stable when stored under standard conditions, away from light, and when formulated with suitable bases. The chemical stability assessments revealed a decline in potency or concentration at elevated temperatures.

Conclusion: The study concludes that, within the parameters of stability evaluated, semi-solid drug preparations remain viable for use.