Escherichia coli dominance and antimicrobial resistance in urinary tract infections among diabetic patients: Insights from Birnin Kebbi Metropolis, Nigeria

Adamu Aliero Almustapha; Haruna Abdullahi Yari; Ahmad Bagudo Ibrahim; Sule Sahabi Manga; Farida Abubakar Tomo; Amina Muhammad; Muhammad Shamsudeen Muhammad

doi:10.20884/1.api.2023.11.1.6231

Adamu Aliero Almustapha Kebbi State University of Science and Technology, Aliero, Nigeria http://orcid.org/0000-0002-1790-1548
Haruna Abdullahi Yari Kebbi State University of Science and Technology, Aliero, Nigeria
Ahmad Bagudo Ibrahim Kebbi State University of Science and Technology, Aliero, Nigeria http://orcid.org/0000-0002-4450-1304
Sule Sahabi Manga Kebbi State University of Science and Technology, Aliero, Nigeria
Farida Abubakar Tomo Kebbi State University of Science and Technology, Aliero, Nigeria http://orcid.org/0000-0003-0408-4224
Amina Muhammad Department of Microbiology, Kebbi State University of Science and Technology Aliero, Nigeria
Muhammad Shamsudeen Muhammad Kebbi State University of Science and Technology, Aliero, Nigeria http://orcid.org/0000-0003-3328-6685

DOI: https://doi.org/10.20884/1.api.2023.11.1.6231

Abstract

Background: The global rise in antibiotic-resistant urinary tract infections (UTIs) is a growing concern, particularly among diabetic patients. This study examines the antibiotic resistance patterns of bacterial uropathogens in diabetic patients at Sir Yahaya Memorial Hospital in Birnin Kebbi.

Methods: A purposive sampling approach was used to collect 51 mid-stream urine samples in sterile containers. Cultural and biochemical methods were employed for the isolation and identification of uropathogenic bacteria. Antibiotic sensitivity testing was performed using the disc diffusion method, with results interpreted according to the Clinical Laboratory Standards Institute (CLSI) guidelines.

Results: UTIs were prevalent in 23.5% (12/51) of the samples. Escherichia coli was the most prevalent uropathogen, accounting for 41.3% (7/17) of cases, followed by Klebsiella pneumoniae at 23.5% (4/17). Staphylococcus aureus and Proteus mirabilis each contributed to 17.6% (3/17) of cases. Notably, E. coli and K. pneumoniae exhibited 100% resistance to chloramphenicol and sparfloxacin, respectively.

Conclusion: These findings underscore the need for further molecular research to characterize these uropathogens and identify the genes contributing to antibiotic resistance.