KORELASI USIA DAN JENIS KELAMIN DENGAN GRADING LIMFOMA NON HODGKIN SEL B DI RSUD PROF. DR. MARGONO SOEKARJO PURWOKERTO
Abstract
Latar Belakang: Limfoma non-Hodgkin (LNH) dibedakan menjadi dua kelompok utama, yaitu limfoma sel B dan limfoma sel T/NK. Tipe LNH paling banyak di dunia adalah LNH sel B. Salah satu cara mengelompokkan LNH sel B yaitu dengan menggunakan pemeriksaan histopatologi untuk membedakan grading menjadi low grade dan high grade. Tingkat kejadian LNH sel B meningkat bertahap berdasarkan usia dan lebih banyak terjadi pada laki-laki. Penelitian ini bertujuan untuk mengetahui apakah terdapat hubungan antara usia dan jenis kelamin dengan grading LNH sel B. Metode: Penelitian ini merupakan penelitian analitik observasional dengan pendekatan cross sectional yang dilakukan pada pasien limfoma non-Hodgkin sel B di RSUD Prof. Dr. Margono Soekarjo Purwokerto pada tahun 2019-2021. Analisis data menggunakan uji Chi-square. Hasil: Total sampel yang didapatkan adalah 75 pasien LNH sel B. Sebanyak 47 (62,7%) pasien berusia <60 tahun dan 28 (37,3%) pasien berusia ⩾60 tahun. Pasien laki-laki berjumlah 40 (53,3%) pasien, lebih banyak daripada perempuan yang berjumlah 35%. Hasil analisis menunjukkan bahwa tidak terdapat hubungan antara usia dengan grading (p=0,617), serta jenis kelamin dengan grading (p=0,366). Kesimpulan: Tidak terdapat hubungan antara usia dengan grading LNH sel B. Tidak terdapat hubungan antara jenis kelamin dengan grading LNH sel B.
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Yakimchuk, K., Iravani, M., Hasni, M. S., Rhönnstad, P., Nilsson, S., Jondal, M., & Okret, S. (2011). Effect of ligand-activated estrogen receptor β on lymphoma growth in vitro and in vivo. Leukemia, 25(7), 1103–1110. https://doi.org/10.1038/leu.2011.68
Ansell, S. M. (2015). Non-Hodgkin Lymphoma: Diagnosis and Treatment. Mayo Clinic Proceedings, 90(8), 1152–1163. https://doi.org/10.1016/j.mayocp.2015.04.025
Asmara, I. G. Y. (2018). Penanda Biologis Limfoma Maligna. Jurnal Kedokteran, 7(4), 40–48.
Bavik, C., Coleman, I., Dean, J. P., Knudsen, B., Plymate, S., & Nelson, P. S. (2006). The Gene Expression Program of Prostate Fibroblast Senescence Modulates Neoplastic Epithelial Cell Proliferation through Paracrine Mechanisms. Cancer Research, 66(2), 794–802. https://doi.org/10.1158/0008-5472.CAN-05-1716
Campisi, J. (2003). Cancer and ageing: Rival demons? Nature Reviews Cancer, 3(5), 339–349. https://doi.org/10.1038/nrc1073
Coppé, J.-P., Patil, C. K., Rodier, F., Sun, Y., Muñoz, D. P., Goldstein, J., Nelson, P. S., Desprez, P.-Y., & Campisi, J. (2008). Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor. PLoS Biology, 6(12), e301. https://doi.org/10.1371/journal.pbio.0060301
Fagagna, F. d’Adda D., Reaper, P. M., Clay-Farrace, L., Fiegler, H., Carr, P., Von Zglinicki, T., Saretzki, G., Carter, N. P., & Jackson, S. P. (2003). A DNA damage checkpoint response in telomere-initiated senescence. Nature, 426(6963), 194–198. https://doi.org/10.1038/nature02118
Gilson, E., & Géli, V. (2007). How telomeres are replicated. Nature Reviews Molecular Cell Biology, 8(10), 825–838. https://doi.org/10.1038/nrm2259
GLOBOCAN. (2020). Cancer Today. https://gco.iarc.fr/today/online-analysis-table?v=2020&mode=cancer&mode_population=continents&population=900&populations=360&key=asr&sex=0&cancer=39&type=1&statistic=5&prevalence=0&population_group=0&ages_group%5B%5D=0&ages_group%5B%5D=17&group_cancer=1&include_nmsc=0&include_nmsc_other=1
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Kemenkes RI. (2020). Jenis Kanker ini Rentan Menyerang Manusia. https://www.kemkes.go.id/article/view/20011400002/jenis-kanker-ini-rentan-menyerang-manusia.html
Lee, J. S., Bracci, P. M., & Holly, E. A. (2008). Non-Hodgkin Lymphoma in Women: Reproductive Factors and Exogenous Hormone Use. American Journal of Epidemiology, 168(3), 278–288. https://doi.org/10.1093/aje/kwn119
Liu, D., & Hornsby, P. J. (2007). Senescent Human Fibroblasts Increase the Early Growth of Xenograft Tumors via Matrix Metalloproteinase Secretion. Cancer Research, 67(7), 3117–3126. https://doi.org/10.1158/0008-5472.CAN-06-3452
Liu, J., Song, B., Fan, T., Huang, C., Xie, C., Li, J., Zhong, W., Li, S., & Yu, J. (2011). Pathological and clinical characteristics of 1,248 non-Hodgkin’s lymphomas from a regional cancer hospital in Shandong, China. Asian Pacific Journal of Cancer Prevention: APJCP, 12(11), 3055–3061.
LRF. (2021). Non-Hodgkin Lymphoma. https://lymphoma.org/aboutlymphoma/nhl/
Martelli, M., Ferreri, A. J. M., Agostinelli, C., Di Rocco, A., Pfreundschuh, M., & Pileri, S. A. (2013). Diffuse large B-cell lymphoma. Critical Reviews in Oncology/Hematology, 87(2), 146–171. https://doi.org/10.1016/j.critrevonc.2012.12.009
Morton, L. M., Slager, S. L., Cerhan, J. R., Wang, S. S., Vajdic, C. M., Skibola, C. F., Bracci, P. M., De Sanjose, S., Smedby, K. E., Chiu, B. C. H., Zhang, Y., Mbulaiteye, S. M., Monnereau, A., Turner, J. J., Clavel, J., Adami, H.-O., Chang, E. T., Glimelius, B., Hjalgrim, H., … Sampson, J. N. (2014). Etiologic Heterogeneity Among Non-Hodgkin Lymphoma Subtypes: The InterLymph Non-Hodgkin Lymphoma Subtypes Project. JNCI Monographs, 2014(48), 130–144. https://doi.org/10.1093/jncimonographs/lgu013
Nolan, J., Saputra, H., Susraini, A. A. A. N., & Sumadi, I. W. J. (2021). PROFIL GAMBARAN LIMFOMA MALIGNUM NON-HODGKIN MENURUT KLASIFIKASI WHO DAN WORKING FORMULATION DI LABORATORIUM PATOLOGI ANATOMI RSUP SANGLAH DENPASAR PERIODE TAHUN 2016 – 2018. JURNAL MEDIKA UDAYANA, 10(9), 38–43.
Pierdominici, M., Maselli, A., Colasanti, T., Giammarioli, A. M., Delunardo, F., Vacirca, D., Sanchez, M., Giovannetti, A., Malorni, W., & Ortona, E. (2010). Estrogen receptor profiles in human peripheral blood lymphocytes. Immunology Letters, 132(1–2), 79–85. https://doi.org/10.1016/j.imlet.2010.06.003
Rachon, D., Mysliwska, J., Suchecka-Rachon, K., Wieckiewicz, J., & Mysliwski, A. (2002). Effects of oestrogen deprivation on interleukin-6 production by peripheral blood mononuclear cells of postmenopausal women. Journal of Endocrinology, 172(2), 387–395. https://doi.org/10.1677/joe.0.1720387
Sapkota, S., & Shaikh, H. (2022). Non-Hodgkin Lymphoma. In Non-Hodgkin Lymphoma. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK559328/
SEER NCI. (2020). Non-Hodgkin Lymphoma—Cancer Stat Facts. SEER. https://seer.cancer.gov/statfacts/html/nhl.html
Sergentanis, T. N., Kanavidis, P., Michelakos, T., & Petridou, E. T. (2013). Cigarette smoking and risk of lymphoma in adults. European Journal of Cancer Prevention, 22(2), 131–150. https://doi.org/10.1097/CEJ.0b013e328355ed08
Song, S., Grody, W. W., & Naeim, F. (2015). Non-Hodgkin Lymphoma. In A. M. Evens & K. A. Blum (Eds.), Hematopathology: Morphology, Immunophenotype, Cytogenetics, and Molecular Approaches (Vol. 165). Springer International Publishing. https://doi.org/10.1007/978-3-319-13150-4
Swerdlow, S. H., Campo, E., Harris, N. L., Jaffe, E. S., Pileri, S. A., Stein, H., & Thiele, J. (2017). WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. IARC.
Swesis, I. A. C., Suega, K., & Rena, N. M. R. A. (2014). Kaitan Faktor Usia dan Jenis Kelamin terhadap Kejadian Limfoma Non Hodgkin di Rumah Sakit Sanglah Tahun 2014.
Xue, W., Zender, L., Miething, C., Dickins, R. A., Hernando, E., Krizhanovsky, V., Cordon-Cardo, C., & Lowe, S. W. (2007). Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature, 445(7128), 656–660. https://doi.org/10.1038/nature05529
Yakimchuk, K., Iravani, M., Hasni, M. S., Rhönnstad, P., Nilsson, S., Jondal, M., & Okret, S. (2011). Effect of ligand-activated estrogen receptor β on lymphoma growth in vitro and in vivo. Leukemia, 25(7), 1103–1110. https://doi.org/10.1038/leu.2011.68
Published
2024-05-25
How to Cite
PANGESTU, Thomas Adi et al.
KORELASI USIA DAN JENIS KELAMIN DENGAN GRADING LIMFOMA NON HODGKIN SEL B DI RSUD PROF. DR. MARGONO SOEKARJO PURWOKERTO.
Mandala Of Health, [S.l.], v. 17, n. 1, p. 51-59, may 2024.
ISSN 2615-6954.
Available at: <https://jos.unsoed.ac.id/index.php/mandala/article/view/9564>. Date accessed: 03 nov. 2025.
doi: https://doi.org/10.20884/1.mandala.2024.17.1.9564.
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