Azadirone-Type Limonoids from the Fruit of Chisocheton lasiocarpus and Their Cytotoxic Activity Against MCF-7 Breast Cancer Lines

Limonoids from Chisocheton lasiocarpus

  • Erina Hilmayanti Universitas Padjadjaran
  • Nurlelasari Nurlelasari Universitas Padjadjaran
  • Dewa Gede Katja Universitas Padjadjaran
  • Ace Tatang Hidayat Universitas Padjadjaran
  • Sofa Fajriah Universitas Padjadjaran
  • Akhmad Darmawan Universitas Padjadjaran
  • Unang Supratman Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Sumedang, Indonesia
  • Mohamad Nurul Azmi
  • Yoshihito Shiono Yamagata University

Abstract

Limonoid is derivatives of triterpenoid compound that have a wide variety of structures due to various ring-opening, rearrangements, and high-degree of oxidation. Limonoid is known as compounds that have wide-range of biological activities, including anticancer activity. This research was aimed to determine the chemical structure and cytotoxic activity of limonoid in the n-hexane extract of Chisocheton lasiocarpus fruit. Dried powder of C. lasiocarpus fruit was extracted using methanol followed by fractionated using n-hexane, ethyl acetate, and n-butanol. Five azadirone-type limonoids, 6α-(acetoxy)-14β,15β-epoxyazadirone (1), dysobinin (2), 7α-acetylneotricilenone (3), 6α-O-acetyl-7-deacetylnimocinol (4), and 7α-hyroxyneotricilenone (5), were isolated from the n-hexane extract of Chisocheton lasiocarpus fruit. The chemical structure of all compounds was identified by spectroscopic analysis, including 1D, 2D-NMR, IR, UV and HR-TOF MS as well as by comparison with previous reported spectra data. Compounds 1-5 were investigated from this plant for first time. The cytotoxic activity of the isolated compounds against MCF-7 breast cancer line were examined and the results showed that 7α-hyroxyneotricilenone (5) showed the moderate activity with IC50 values of 53 μM

Published
2022-03-13
How to Cite
HILMAYANTI, Erina et al. Azadirone-Type Limonoids from the Fruit of Chisocheton lasiocarpus and Their Cytotoxic Activity Against MCF-7 Breast Cancer Lines. Molekul, [S.l.], v. 17, n. 1, p. 60-67, mar. 2022. ISSN 2503-0310. Available at: <http://jos.unsoed.ac.id/index.php/jm/article/view/5593>. Date accessed: 05 oct. 2022. doi: https://doi.org/10.20884/1.jm.2022.17.1.5593.
Section
Articles

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