RENOPROTEKTIF EKSTRAK ETANOL GANODERMA LUCIDIUM PADA TIKUS PUTIH MODEL GAGAL GINJAL AKUT YANG DIINDUKSI DIETILEN GLIKOL

Abstract

Diethylene glycol (DEG) is a solvent with a sweet taste that is often misused as a solvent for syrup drugs for pediatric patients, causing acute renal failure. Decreased kidney function is characterized by increased levels of urea nitrogen and blood creatinine and homeostatic disorders of blood electrolyte fluids such as sodium, potassium, calcium and chloride. Ganoderma lucidum (Ling Zhi mushroom) is known as medicinal mushroom which contains active compounds including triterpenoids and flavonoids. Ganoderma is expected to be a substitute for chemical drugs and hemolysis therapy in pediatric patients with acute renal failure. The purpose of the study was to determine the potential of Ganoderma as a kidney protector from exposure to diethylene glycol. Twenty-four rats were used in the study and divided into six groups with four replications. Group 1 as healthy controls, group 2 DEG-induced as sick control dose 5g/kgBW. Groups 3,4 and 5 were given Ganoderma for 7 days at doses of 250 mg/kgBW, 500 mg/KgBB and 750 mg/KgBB and DEG-induced at doses of 5 g/kgBW for 5 days. Group 6 as a comparison was given anti-nephrotoxic drugs  at dose of  5g / kgBW and then induced DEG for 5 days. The observed parameters include urea nitrogen levels, creatinine on day 11. The data were analyzed with the Anova test and continued with the Duncan test. Conclusion G. lucidum extract can function as a renoprotector in rat model acute renal failure incuced by DEG  in terms of urea N and creatinine levels. The dose of G. Lucidum extract that  is quite effective as a renoprotective  is at a dose of  500 mg / kg body weight.