PENGARUH PEMBERIAN SARI MARKISA UNGU (Passiflora edulis var edulis) TERHADAP PROFIL LIPID TIKUS WISTAR MODEL DIABETES MELITUS

-

Abstrak

Diabetes mellitus (DM) is a metabolic disorder characterized by increased blood glucose (hyperglycemia) and impairment of metabolism of carbohydrates, protein, and lipid. Impairment of metabolism lipid characterized by increased total cholesterol, triglyceride, LDL, and decreased HDL. Purple passion fruit contains many nutrients that can be improved lipid profile. This study aimed to determine the effect of purple passion fruit juice (Passiflora edulis var edulis) on the serum lipid profile of male DM rats (Rattus norvegicus). The profile lipid parameter was observed total cholesterol, triglyceride, LDL, and HDL. This true experimental study used 30 Wistar strain male rats (Rattus norvegicus) which were divided into 5 groups: I (normal control), II (DM control), and III, IV, V purple passion fruit juice treatment dose of 1.05ml, 2.1ml, and 4.2ml/200gBW/day, respectively, through sonde for 21 days. Diabetes induction was made intraperitoneal by a single dose of alloxan 120mg/kg BW and was successful if the blood glucose levels were>200 mg/dL. Lipid profiles were analyzed with the enzymatic-photometric method. The result of this experiment was analyzed by One Way ANOVA parametric test and Kruskal-Wallis non-parametric test. The result of this experiment is there is no significant effect lipid profile between groups (p>0,05). This study concludes that the provision of purple passion fruit juice (Passiflora edulis var edulis) did not affect the serum lipid profile of male DM rats.