Dammarane-Type Triterpenoids from Twigs of Aglaia Foveolata and Their Antibacterial Activity

  • Ricson Pemimpin Hutagaol Department of Chemistry, Faculty of Mathematics and Natural sciences, Nusa Bangsa University, Bogor 16166, Indonesia
  • Tjandrawati Mozef Research Center for Pharmaceutical Ingredients and Traditional Medicine, National Research and Innovation Agency (BRIN), Serpong Tangerang Selatan 15314, Indonesia
  • Febi Nurilmala Department of Biologi, Faculty of Mathematics and Natural sciences, Nusa Bangsa University, Bogor 16166, Indonesia
  • Gian Primahana Research Center for Pharmaceutical Ingredients and Traditional Medicine, National Research and Innovation Agency (BRIN), Serpong Tangerang Selatan 15314, Indonesia
  • Sofa Fajriah Research Center for Pharmaceutical Ingredients and Traditional Medicine, National Research and Innovation Agency (BRIN), Serpong Tangerang Selatan 15314, Indonesia
  • Muhammad Eka Prastya Research Center for Pharmaceutical Ingredients and Traditional Medicine, National Research and Innovation Agency (BRIN), Serpong Tangerang Selatan 15314, Indonesia
  • Sigit Hidayatullah Department of Chemistry, Faculty of Mathematics and Natural sciences, Nusa Bangsa University, Bogor 16166, Indonesia
  • Desy Satyaningsih Department of Chemistry, Faculty of Mathematics and Natural sciences, Nusa Bangsa University, Bogor 16166, Indonesia
DOI: https://doi.org/10.20884/1.jm.2025.20.2.16241

Abstract

ABSTRACT. The Aglaia species, which contains triterpenoids, is the most numerous in the Meliaceae family. Aglaia foveolata (A. foveolata) is a type of plant that has many benefits, as medicinal ingredients. The potential of this plant is inseparable from the content of various bioactive compounds. This study aims to isolate, characterize the active compound from the twigs of A. foveolata and test its activity as an antibacterial. Three dammarane-type triterpenoids were isolated from the A. foveolata twigs which is, namely dammar-24-en-3β,20-diol (1), an epimeric mixture of shoreic and eichlerianic acid (2, 3). Their chemical structures were determined based on spectroscopic data using infrared, high-resolution mass spectrometry, and including one and two-dimensional NMR techniques, as well as through data comparison of the reported compound. Compound 1 was reported for the first time to be successfully isolated from this species. All these substances were tested for the first time for their antibacterial activity against two Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis and two Gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa, through this study. Compound 1 was inactive, the epimeric mixture of 2 and 3 showed moderate antibacterial activity with a minimum inhibitory concentration (MIC) value ranging from 31.7 to 126.6 ppm, particularly against S. aureus with a MIC value of 31.7 ppm.  


 


Keywords: Aglaia, Elucidation, Isolation, Spectroscopy, Bacterial

Published
2025-07-24
How to Cite
HUTAGAOL, Ricson Pemimpin et al. Dammarane-Type Triterpenoids from Twigs of Aglaia Foveolata and Their Antibacterial Activity. Molekul, [S.l.], v. 20, n. 2, p. 394-403, july 2025. ISSN 2503-0310. Available at: <https://jos.unsoed.ac.id/index.php/jm/article/view/16241>. Date accessed: 20 aug. 2025. doi: https://doi.org/10.20884/1.jm.2025.20.2.16241.
Citation Formats
Issue
Vol 20 No 2 (2025)
Section
Biomolecule Isolation, Modification and Application

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