Effect of Cosolvent and Polymer on LTG-OF HPMC P.603/PVA-based Lamotrigine Orodispersible Film: Optimization and Physicochemical Characterization

Effect of Cosolvent and Polymer on HPMC P.603/PVA-based Lamotrigine Orodispersible Film

  • Nining Nining Department of Pharmaceutical Technology, Faculty of Pharmacy and Science, Universitas Muhammadiyah Prof. DR. HAMKA, Jakarta 13460, Indonesia
  • Anisa Amalia Department of Pharmaceutical Technology, Faculty of Pharmacy and Science, Universitas Muhammadiyah Prof. DR. HAMKA, Jakarta 13460, Indonesia http://orcid.org/0000-0002-3631-4090
  • Clara Benita Undergraduate Program of Pharmacy, Department of Pharmaceutical Technology, Faculty of Pharmacy and Science, Universitas Muhammadiyah Prof. DR. HAMKA, Jakarta 13460, Indonesia
  • Agnes Aga Andriyani Undergraduate Program of Pharmacy, Department of Pharmaceutical Technology, Faculty of Pharmacy and Science, Universitas Muhammadiyah Prof. DR. HAMKA, Jakarta 13460, Indonesia
  • Supandi Supandi Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Science, Universitas Muhammadiyah Prof. DR. HAMKA, Jakarta 13460, Indonesia
DOI: https://doi.org/10.20884/1.jm.2025.20.3.12949

Abstract

ABSTRACT. Lamotrigine (LTG), classified as BCS class II, is dissolved in cosolvent ethanol (EtOH) or ethyl acetate (EA) to enhance solubility. The objectives of this study are to identify the appropriate formulation of LTG orodispersible film (OF) based on hydroxypropyl methylcellulose Pharmacoat® 603 and polyvinyl alcohol (HPMC P.603/PVA) polymer with EtOH or EA solvency using Central Composite Design in Response Surface Methodology (CCD-RSM). An experimental approach was utilized to investigate the effect of cosolvent amount and HPMC P.603/PVA ratios on the film disintegration time (DT) and folding endurance (FE). The optimized OF-EA composition was 0.46 HPMC P.603/PVA ratio and 3.66% EA with a desirability of 0.817. In comparison, the optimal OF-EtOH composition was 0.87 HPMC P.603/PVA ratio and 6.19% EtOH with a desirability of 0.843. The characteristic data for the optimal formulas include: OF-EtOH: weight variation 92.05±4.81 mg, thickness 0.15±0.01 mm, DT 36.11±1.48 sec, and FE 310.33±5.03; and OF-EA: weight variation 93.72±1.50 mg, thickness 0.16±0.00 mm, DT 26.73±3.32 sec, and FE 470.6±37.44. Based on the OF-EtOH FE, the HPMC P.603/PVA ratio had a greater effect compared to the amount of EtOH (p<0.05). The analysis of variance (ANOVA) demonstrated that the amount of EA had a greater impact compared to the HPMC P.603/PVA ratio, with statistical significance (p<0.05). The EtOH cosolvent was preferable to EA based on the LTG solubility and OF dissolution profile. LTG OF had favorable physicochemical properties and showed promise as a rapid-dissolving formulation for therapeutic purposes.


 


Keywords: Central composite design, cosolvency, disintegration time, folding endurance, oral film.


 

Published
2025-11-24
How to Cite
NINING, Nining et al. Effect of Cosolvent and Polymer on LTG-OF HPMC P.603/PVA-based Lamotrigine Orodispersible Film: Optimization and Physicochemical Characterization. Molekul, [S.l.], v. 20, n. 3, p. 475-486, nov. 2025. ISSN 2503-0310. Available at: <https://jos.unsoed.ac.id/index.php/jm/article/view/12949>. Date accessed: 26 nov. 2025. doi: https://doi.org/10.20884/1.jm.2025.20.3.12949.
Citation Formats
Issue
Vol 20 No 3 (2025)
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Articles

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