Factors Affecting Adherence to Antihypertensive Medication: Systematic Review
Abstract
Introduction: Hypertension is one of the most common cardiovascular diseases around the world. Hypertension influence so many aspect in patient’s live, not only physically but psychologically as well. Identifying and understanding factors related with treatment adherence in patient with hypertension can be very important to develop specific strategies to increase patient’s quality of life, prevent complications, and reduce re-hospitalization rate in patient with hypertension.
Objective: This paper reviewed and synthesized the previous studies of factors related with treatment adherence in patient with hypertension.
Method: Literature study in 15 journals through Cumulative Index to Nursing and Allied Health Literature (CINAHL), PubMed, Ovid, Taylor and Francis, and Science Direct, and manual searching from the reference list of previous obtained using keywords definition of treatment adherence, dimension of treatment adherence in patient with hypertension, and factors related with treatment adherence in patient with hypertension. Data were analyzed in tables contain title, author, year, methodology, result, and recommendation.
Result: Patient adherence to treatment can be describe as an extent of patient’s behavior to follow the medication, diet, and lifestyle changes as recommended by the healthcare provider. Treatment adherence represents patient’s behavior after discussion between patient and healthcare provider. Patient have right to agree or refuse the treatment after get enough information from healthcare provider.
Conclusion: The individualized approach can be very useful to assess and understand the cause of patient non-adherence with treatment hypertension. In the future this information can be useful to decide nursing theory that fit to underpinning the intervention and also can be used to plan intervention to increase treatment adherence of patient with hypertension.
References
Al-Ramahi, R. (2015). Adherence to medications and associated factors: A cross-sectional study among Palestinian hypertensive patients. Journal of epidemiology and global health, 5(2), 125-132.
Amaral, O., Chaves, C., Duarte, J., Coutinho, E., Nelas, P., & Preto, O. (2015). Treatment Adherence in Hypertensive Patients–A Cross-sectional Study. Procedia-Social and Behavioral Sciences, 171, 1288-1295.
Baggarly, S. A., Kemp, R. J., Wang, X., & Magoun, A. D. (2014). Factors associated with medication adherence and persistence of treatment for hypertension in a Medicaid population. Research in Social and Administrative Pharmacy, 10(6), e99-e112.
Bautista, L. E., Vera-Cala, L. M., Colombo, C., & Smith, P. (2012). Symptoms of depression and anxiety and adherence to antihypertensive medication. American journal of Hypertension, 25(4), 505-511.
Bissonnette, J. M. (2008). Adherence: a concept analysis. Journal of Advanced Nursing, 63(6), 634-643.
Byrd, C. E. (2004). Understanding Adherence to the Typical Anti-hypertensive Treatment Regimen: An Expanded Self-regulation Theory Based Prediction Model (Doctoral dissertation, University of Florida).
Chaturvedi, M., Jindal, S., & Kumar, R. (2009). Lifestyle modification in hypertension in the Indian context. J Indian Acad Commun Med, 10, 46-51.
Chen, S. L., Tsai, J. C., & Chou, K. R. (2011). Illness perceptions and adherence to therapeutic regimens among patients with hypertension: A structural modeling approach. International journal of nursing studies, 48(2), 235-245.
da Silva, A. P., Avelino, F. V. S. D., Sousa, C. L. A., da Costa Valle, A. R. M., & Figueiredo, M. D. L. F. (2016). Factors associated with non-adherence to treatment of hypertension: an integrative review. Revista de Pesquisa: Cuidado é Fundamental Online, 8(1), 4047-4055.
Dennison, C. R., & Miller, N. H. (2008). Adherence to antihypertensive therapy. Hypertension Primer: The Essentials of High Blood Pressure, 4th ed. Pennsylvania: Lippincott Williams & Wilkins, 413-417.
Fava, S. M. C. L., Teraoka, E. C., Oliveira, A. D. S., Calixto, A. A. T. F., Eid, L. P., & Veiga, E. V. (2014). Fatores relacionados à adesão ao tratamento da hipertensão arterial sistêmica. Revista da Rede de Enfermagem do Nordeste-Rev Rene, 15(2).
Frisoli, T. M., Schmieder, R. E., Grodzicki, T., & Messerli, F. H. (2011). Beyond salt: lifestyle modifications and blood pressure. European heart journal, ehr379.
Gascón, J. J., Sánchez-Ortuño, M., Llor, B., Skidmore, D., Saturno, P. J., & Treatment Compliance in Hypertension Study Group. (2004). Why hypertensive patients do not comply with the treatment results from a qualitative study. Family practice, 21(2), 125-130.
Hashmi, S. K., Afridi, M. B., Abbas, K., Sajwani, R. A., Saleheen, D., Frossard, P. M., ... & Ahmad, U. (2007). Factors associated with adherence to anti-hypertensive treatment in Pakistan. PLoS One, 2(3), e280.
He, W., Bonner, A., & Anderson, D. (2015). Patient reported adherence to hypertension treatment: A revalidation study. European Journal of Cardiovascular Nursing, 1474515115603902.
Hendriks, M. E., Wit, F. W., Akande, T. M., Kramer, B., Osagbemi, G. K., Tanović, Z., ... & Schultsz, C. (2014). Effect of health insurance and facility quality improvement on blood pressure in adults with hypertension in Nigeria: a population-based study. JAMA internal medicine, 174(4), 555-563.
Hsiao, C. Y., Chang, C., & Chen, C. D. (2012). An investigation on illness perception and adherence among hypertensive patients. The Kaohsiung journal of medical sciences, 28(8), 442-447.
Irvin, M. R., Shimbo, D., Mann, D. M., Reynolds, K., Krousel‐Wood, M., Limdi, N. A., ... & Muntner, P. (2012). Prevalence and Correlates of Low Medication Adherence in Apparent Treatment‐Resistant Hypertension. The Journal of Clinical Hypertension, 14(10), 694-700.
Jin, J., Sklar, G. E., Oh, V. M. S., & Li, S. C. (2008). Factors affecting therapeutic compliance: A review from the patient's perspective.Therapeutics and clinical risk management, 4(1), 269.
Kamran, A., Azadbakht, L., Sharifirad, G., Mahaki, B., & Sharghi, A. (2014). Sodium intake, dietary knowledge, and illness perceptions of controlled and uncontrolled rural hypertensive patients. International journal of hypertension,2014.
Kaplan, N. M., & Victor, R.G. (2010). Clinical Hypertension. Philadelphia:Lippincott William & Wilkins.
Karaeren, H., Yokusoglu, M., Uzun, S., Baysan, O., Koz, C., Kara, B., ... & Uzun, M. (2009). The effect of the content of the knowledge on adherence to medication in hypertensive patients. Anadolu Kardiyol Derg, 9(3), 183-188.
Khan, M. U., Shah, S., & Hameed, T. (2014). Barriers to and determinants of medication adherence among hypertensive patients attended National Health Service Hospital, Sunderland. Journal of pharmacy & bioallied sciences,6(2), 104-108.
Khanam, M. A., Lindeboom, W., Koehlmoos, T. L. P., Alam, D. S., Niessen, L., & Milton, A. H. (2014). Hypertension: adherence to treatment in rural Bangladesh–findings from a population-based study. Global health action, 7.
Khatib, R., Schwalm, J. D., Yusuf, S., Haynes, R. B., McKee, M., Khan, M., & Nieuwlaat, R. (2014). Patient and healthcare provider barriers to hypertension awareness, treatment and follow up: a systematic review and meta-analysis of qualitative and quantitative studies. PLoS One, 9(1), e84238.
Li, W. W., Wallhagen, M. I., & Froelicher, E. S. (2008). Hypertension control, predictors for medication adherence and gender differences in older Chinese immigrants. Journal of advanced nursing, 61(3), 326-335.
Li, W., Liu, L., Puente, J. G., Li, Y., Jiang, X., Jin, S., ... & Ma, S. (2005). Hypertension and health-related quality of life: an epidemiological study in patients attending hospital clinics in China. Journal of hypertension, 23(9), 1667-1676.
Ma, C., Chen, S., Zhou, Y., & Huang, C. (2013). Treatment adherence of Chinese patients with hypertension: A longitudinal study. Applied Nursing Research, 26(4), 225-231.
Magrin, M. E., D’Addario, M., Greco, A., Miglioretti, M., Sarini, M., Scrignaro, M., ... & Crocetti, E. (2015). Social support and adherence to treatment in hypertensive patients: a meta-analysis. Annals of Behavioral Medicine, 49(3), 307-318.
Malik, A., Yoshida, Y., Erkin, T., Salim, D., & Hamajima, N. (2014). Hypertension-related knowledge, practice and drug adherence among inpatients of a hospital in Samarkand, Uzbekistan. Nagoya journal of medical science, 76(3-4), 255.
Mazzaglia, G., Ambrosioni, E., Alacqua, M., Filippi, A., Sessa, E., Immordino, V., ... & Mantovani, L. G. (2009). Adherence to antihypertensive medications and cardiovascular morbidity among newly diagnosed hypertensive patients. Circulation, 120(16), 1598-1605.
Midlöv, P., Ekesbo, R., Johansson, L., Gerward, S., Persson, K., Nerbrand, C., & Hedblad, B. (2008). Barriers to adherence to hypertension guidelines among GPs in southern Sweden: a survey. Scandinavian journal of primary health care, 26(3), 154-159.
Moura, A. A. D., Godoy, S. D., Tognoli, S. H., & Mendes, I. A. C. (2015). Adherence to arterial hypertension treatment in the primary health care context: an integrative review. Journal of Nursing UFPE on line [JNUOL/DOI: 10.5205/01012007/Impact factor: RIC: 0, 9220], 9(4), 7420-7430.
Natarajan, S., Santa Ana, E. J., Liao, Y., Lipsitz, S. R., & McGee, D. L. (2009). Effect of treatment and adherence on ethnic differences in blood pressure control among adults with hypertension. Annals of epidemiology,19(3), 172-179.
Rahman, A. R. A., Wang, J. G., Kwong, G. M. Y., Morales, D. D., Sritara, P., & Sukmawan, R. (2015). Perception of hypertension management by patients and doctors in Asia: potential to improve blood pressure control.Asia Pacific family medicine, 14(1), 1.
Shead, V. (2010). Implementation of Hypertension Treatment Recommendations. All Theses and Dissertations (ETDS). Washington University. St.Louis
Sluijs, E., Dulmen. S. V., Dijk. L.V.,Ridder. D. D., Heerdink., & Bensing. Jozien. (2006). Patient adherence to medical treatment: a meta review. NETHERLAND:NIVEL
Stavropoulou, C. (2012). Perceived information needs and non‐adherence: evidence from Greek patients with hypertension. Health Expectations, 15(2), 187-196.
Trinder, Y. (2012). Common and less common adverse effects of antihypertensives: a general practitioner's perspective. South African Family Practice, 54(2), S31-S32.
Trivedi, R. B., Ayotte, B., Edelman, D., & Bosworth, H. B. (2008). The association of emotional well-being and marital status with treatment adherence among patients with hypertension. Journal of behavioral medicine,31(6), 489-497.
Venkatachalam, J., Abrahm, S. B., Singh, Z., Stalin, P., & Sathya, G. R. (2015). Determinants of patient's adherence to hypertension medications in a rural population of Kancheepuram District in Tamil Nadu, South India. Indian journal of community medicine: official publication of Indian Association of Preventive & Social Medicine, 40(1), 33.
Wang, R., Zhao, Y., He, X., Ma, X., Yan, X., Sun, Y., ... & He, J. (2009). Impact of hypertension on health-related quality of life in a population-based study in Shanghai, China. Public health, 123(8), 534-539.
Wang, W., Lau, Y., Loo, A., Chow, A., & Thompson, D. R. (2014). Medication adherence and its associated factors among Chinese community-dwelling older adults with hypertension. Heart & Lung: The Journal of Acute and Critical Care, 43(4), 278-283.
Will, J. C., Zhang, Z., Ritchey, M. D., & Loustalot, F. (2015). Medication Adherence and Incident Preventable Hospitalizations for Hypertension.American journal of preventive medicine.
Yiannakopoulou, E. C., Papadopulos, J. S., Cokkinos, D. V., & Mountokalakis, T. D. (2005). Adherence to antihypertensive treatment: a critical factor for blood pressure control. European Journal of Cardiovascular Prevention & Rehabilitation, 12(3), 243-249.
Amaral, O., Chaves, C., Duarte, J., Coutinho, E., Nelas, P., & Preto, O. (2015). Treatment Adherence in Hypertensive Patients–A Cross-sectional Study. Procedia-Social and Behavioral Sciences, 171, 1288-1295.
Baggarly, S. A., Kemp, R. J., Wang, X., & Magoun, A. D. (2014). Factors associated with medication adherence and persistence of treatment for hypertension in a Medicaid population. Research in Social and Administrative Pharmacy, 10(6), e99-e112.
Bautista, L. E., Vera-Cala, L. M., Colombo, C., & Smith, P. (2012). Symptoms of depression and anxiety and adherence to antihypertensive medication. American journal of Hypertension, 25(4), 505-511.
Bissonnette, J. M. (2008). Adherence: a concept analysis. Journal of Advanced Nursing, 63(6), 634-643.
Byrd, C. E. (2004). Understanding Adherence to the Typical Anti-hypertensive Treatment Regimen: An Expanded Self-regulation Theory Based Prediction Model (Doctoral dissertation, University of Florida).
Chaturvedi, M., Jindal, S., & Kumar, R. (2009). Lifestyle modification in hypertension in the Indian context. J Indian Acad Commun Med, 10, 46-51.
Chen, S. L., Tsai, J. C., & Chou, K. R. (2011). Illness perceptions and adherence to therapeutic regimens among patients with hypertension: A structural modeling approach. International journal of nursing studies, 48(2), 235-245.
da Silva, A. P., Avelino, F. V. S. D., Sousa, C. L. A., da Costa Valle, A. R. M., & Figueiredo, M. D. L. F. (2016). Factors associated with non-adherence to treatment of hypertension: an integrative review. Revista de Pesquisa: Cuidado é Fundamental Online, 8(1), 4047-4055.
Dennison, C. R., & Miller, N. H. (2008). Adherence to antihypertensive therapy. Hypertension Primer: The Essentials of High Blood Pressure, 4th ed. Pennsylvania: Lippincott Williams & Wilkins, 413-417.
Fava, S. M. C. L., Teraoka, E. C., Oliveira, A. D. S., Calixto, A. A. T. F., Eid, L. P., & Veiga, E. V. (2014). Fatores relacionados à adesão ao tratamento da hipertensão arterial sistêmica. Revista da Rede de Enfermagem do Nordeste-Rev Rene, 15(2).
Frisoli, T. M., Schmieder, R. E., Grodzicki, T., & Messerli, F. H. (2011). Beyond salt: lifestyle modifications and blood pressure. European heart journal, ehr379.
Gascón, J. J., Sánchez-Ortuño, M., Llor, B., Skidmore, D., Saturno, P. J., & Treatment Compliance in Hypertension Study Group. (2004). Why hypertensive patients do not comply with the treatment results from a qualitative study. Family practice, 21(2), 125-130.
Hashmi, S. K., Afridi, M. B., Abbas, K., Sajwani, R. A., Saleheen, D., Frossard, P. M., ... & Ahmad, U. (2007). Factors associated with adherence to anti-hypertensive treatment in Pakistan. PLoS One, 2(3), e280.
He, W., Bonner, A., & Anderson, D. (2015). Patient reported adherence to hypertension treatment: A revalidation study. European Journal of Cardiovascular Nursing, 1474515115603902.
Hendriks, M. E., Wit, F. W., Akande, T. M., Kramer, B., Osagbemi, G. K., Tanović, Z., ... & Schultsz, C. (2014). Effect of health insurance and facility quality improvement on blood pressure in adults with hypertension in Nigeria: a population-based study. JAMA internal medicine, 174(4), 555-563.
Hsiao, C. Y., Chang, C., & Chen, C. D. (2012). An investigation on illness perception and adherence among hypertensive patients. The Kaohsiung journal of medical sciences, 28(8), 442-447.
Irvin, M. R., Shimbo, D., Mann, D. M., Reynolds, K., Krousel‐Wood, M., Limdi, N. A., ... & Muntner, P. (2012). Prevalence and Correlates of Low Medication Adherence in Apparent Treatment‐Resistant Hypertension. The Journal of Clinical Hypertension, 14(10), 694-700.
Jin, J., Sklar, G. E., Oh, V. M. S., & Li, S. C. (2008). Factors affecting therapeutic compliance: A review from the patient's perspective.Therapeutics and clinical risk management, 4(1), 269.
Kamran, A., Azadbakht, L., Sharifirad, G., Mahaki, B., & Sharghi, A. (2014). Sodium intake, dietary knowledge, and illness perceptions of controlled and uncontrolled rural hypertensive patients. International journal of hypertension,2014.
Kaplan, N. M., & Victor, R.G. (2010). Clinical Hypertension. Philadelphia:Lippincott William & Wilkins.
Karaeren, H., Yokusoglu, M., Uzun, S., Baysan, O., Koz, C., Kara, B., ... & Uzun, M. (2009). The effect of the content of the knowledge on adherence to medication in hypertensive patients. Anadolu Kardiyol Derg, 9(3), 183-188.
Khan, M. U., Shah, S., & Hameed, T. (2014). Barriers to and determinants of medication adherence among hypertensive patients attended National Health Service Hospital, Sunderland. Journal of pharmacy & bioallied sciences,6(2), 104-108.
Khanam, M. A., Lindeboom, W., Koehlmoos, T. L. P., Alam, D. S., Niessen, L., & Milton, A. H. (2014). Hypertension: adherence to treatment in rural Bangladesh–findings from a population-based study. Global health action, 7.
Khatib, R., Schwalm, J. D., Yusuf, S., Haynes, R. B., McKee, M., Khan, M., & Nieuwlaat, R. (2014). Patient and healthcare provider barriers to hypertension awareness, treatment and follow up: a systematic review and meta-analysis of qualitative and quantitative studies. PLoS One, 9(1), e84238.
Li, W. W., Wallhagen, M. I., & Froelicher, E. S. (2008). Hypertension control, predictors for medication adherence and gender differences in older Chinese immigrants. Journal of advanced nursing, 61(3), 326-335.
Li, W., Liu, L., Puente, J. G., Li, Y., Jiang, X., Jin, S., ... & Ma, S. (2005). Hypertension and health-related quality of life: an epidemiological study in patients attending hospital clinics in China. Journal of hypertension, 23(9), 1667-1676.
Ma, C., Chen, S., Zhou, Y., & Huang, C. (2013). Treatment adherence of Chinese patients with hypertension: A longitudinal study. Applied Nursing Research, 26(4), 225-231.
Magrin, M. E., D’Addario, M., Greco, A., Miglioretti, M., Sarini, M., Scrignaro, M., ... & Crocetti, E. (2015). Social support and adherence to treatment in hypertensive patients: a meta-analysis. Annals of Behavioral Medicine, 49(3), 307-318.
Malik, A., Yoshida, Y., Erkin, T., Salim, D., & Hamajima, N. (2014). Hypertension-related knowledge, practice and drug adherence among inpatients of a hospital in Samarkand, Uzbekistan. Nagoya journal of medical science, 76(3-4), 255.
Mazzaglia, G., Ambrosioni, E., Alacqua, M., Filippi, A., Sessa, E., Immordino, V., ... & Mantovani, L. G. (2009). Adherence to antihypertensive medications and cardiovascular morbidity among newly diagnosed hypertensive patients. Circulation, 120(16), 1598-1605.
Midlöv, P., Ekesbo, R., Johansson, L., Gerward, S., Persson, K., Nerbrand, C., & Hedblad, B. (2008). Barriers to adherence to hypertension guidelines among GPs in southern Sweden: a survey. Scandinavian journal of primary health care, 26(3), 154-159.
Moura, A. A. D., Godoy, S. D., Tognoli, S. H., & Mendes, I. A. C. (2015). Adherence to arterial hypertension treatment in the primary health care context: an integrative review. Journal of Nursing UFPE on line [JNUOL/DOI: 10.5205/01012007/Impact factor: RIC: 0, 9220], 9(4), 7420-7430.
Natarajan, S., Santa Ana, E. J., Liao, Y., Lipsitz, S. R., & McGee, D. L. (2009). Effect of treatment and adherence on ethnic differences in blood pressure control among adults with hypertension. Annals of epidemiology,19(3), 172-179.
Rahman, A. R. A., Wang, J. G., Kwong, G. M. Y., Morales, D. D., Sritara, P., & Sukmawan, R. (2015). Perception of hypertension management by patients and doctors in Asia: potential to improve blood pressure control.Asia Pacific family medicine, 14(1), 1.
Shead, V. (2010). Implementation of Hypertension Treatment Recommendations. All Theses and Dissertations (ETDS). Washington University. St.Louis
Sluijs, E., Dulmen. S. V., Dijk. L.V.,Ridder. D. D., Heerdink., & Bensing. Jozien. (2006). Patient adherence to medical treatment: a meta review. NETHERLAND:NIVEL
Stavropoulou, C. (2012). Perceived information needs and non‐adherence: evidence from Greek patients with hypertension. Health Expectations, 15(2), 187-196.
Trinder, Y. (2012). Common and less common adverse effects of antihypertensives: a general practitioner's perspective. South African Family Practice, 54(2), S31-S32.
Trivedi, R. B., Ayotte, B., Edelman, D., & Bosworth, H. B. (2008). The association of emotional well-being and marital status with treatment adherence among patients with hypertension. Journal of behavioral medicine,31(6), 489-497.
Venkatachalam, J., Abrahm, S. B., Singh, Z., Stalin, P., & Sathya, G. R. (2015). Determinants of patient's adherence to hypertension medications in a rural population of Kancheepuram District in Tamil Nadu, South India. Indian journal of community medicine: official publication of Indian Association of Preventive & Social Medicine, 40(1), 33.
Wang, R., Zhao, Y., He, X., Ma, X., Yan, X., Sun, Y., ... & He, J. (2009). Impact of hypertension on health-related quality of life in a population-based study in Shanghai, China. Public health, 123(8), 534-539.
Wang, W., Lau, Y., Loo, A., Chow, A., & Thompson, D. R. (2014). Medication adherence and its associated factors among Chinese community-dwelling older adults with hypertension. Heart & Lung: The Journal of Acute and Critical Care, 43(4), 278-283.
Will, J. C., Zhang, Z., Ritchey, M. D., & Loustalot, F. (2015). Medication Adherence and Incident Preventable Hospitalizations for Hypertension.American journal of preventive medicine.
Yiannakopoulou, E. C., Papadopulos, J. S., Cokkinos, D. V., & Mountokalakis, T. D. (2005). Adherence to antihypertensive treatment: a critical factor for blood pressure control. European Journal of Cardiovascular Prevention & Rehabilitation, 12(3), 243-249.
Published
2023-08-24
How to Cite
HIDAYAT, Arif Imam et al.
Factors Affecting Adherence to Antihypertensive Medication: Systematic Review.
International Journal of Biomedical Nursing Review, [S.l.], v. 2, n. 2, p. 1-10, aug. 2023.
ISSN 2962-4703.
Available at: <https://jos.unsoed.ac.id/index.php/ijbnr/article/view/9127>. Date accessed: 19 jan. 2025.
doi: https://doi.org/10.20884/1.ijbnr.2023.2.1.9127.
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