EFFECT OF CIPLUKAN (Physalis angulata L.) EXTRACT ON ANGIOTENSIN II AND BLOOD GLUCOSE LEVELS OF DIABETIC RATS MODEL

Wahyu Siswandari; Thianti Sylviningrum; Yudhi Wibowo; Fitranto Arjadi; Nur Signa Aini Gumilas; Dhadhang Wahyu Kurniawan

Wahyu Siswandari Department of Clinical Pathology, Faculty of Medicine, Universitas Jenderal Soedirman, Purwokerto, Indonesia
Thianti Sylviningrum Department of Dermatovenerology, Faculty of Medicine, Universitas Jenderal Soedirman, Purwokerto, Indonesia
Yudhi Wibowo Department of Public Health, Faculty of Medicine, Universitas Jenderal Soedirman, Purwokerto, Indonesia
Fitranto Arjadi Department of Anatomy, Faculty of Medicine, Universitas Jenderal Soedirman, Purwokerto, Indonesia
Nur Signa Aini Gumilas Department of Histology, Faculty of Medicine, Universitas Jenderal Soedirman, Purwokerto, Indonesia
Dhadhang Wahyu Kurniawan Department of Pharmacy, Faculty of Health Sciences, Universitas Jenderal Soedirman, Purwokerto, Indonesia

Abstract

Diabetes mellitus (DM) is a metabolic disease that can cause various complications, including liver and kidney fibrosis. Angiotensin II is a substance that plays a role in the development of fibrosis through the mechanism of insulin resistance. Ciplukan (Physalis angulata L.) contains various active compounds, including physalin B, D, and F, with physalin B and D known to have antifibrotic effects. This study aims to determine the effect of different doses of Ciplukan on Angiotensin II levels and blood glucose in a diabetic rat model. The study design used a pre and post-test with a control group design. A total of 25 male Wistar rats (Rattus norvegicus) were divided into five groups: healthy control group [1], disease control group [2], administration of Ciplukan extract at a dose of 75 mg/kgBW [3], 150 mg/kgBW [4], and 300 mg/kgBW [5]. The results of the paired t-test showed significant differences in Angiotensin II levels in groups 3, 4, and 5, with p-values of 0.001, 0.004, and 0.05, respectively, and significant differences in blood glucose levels in groups 4 and 5 (p=0.001 and 0.035). The ANOVA test showed that Ciplukan did not affect Angiotensin II levels but affected blood glucose levels, with an effective 150 mg/kg BW dose.