Sesquiterpenoids from Stem Bark of Chisocheton lasiocarpus and Their Cytotoxic Activity against MCF-7 Breast Cancer Cell

  • Unang Supratman Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Sumedang, Indonesia
  • Samuel San Parulian Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor
  • Nurlelasari Nurlelasari Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor
  • Al Arofatus Naini Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor
  • Tri Mayanti Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor
  • Erina Hilmayanti Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor
  • Desi Harneti Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor
  • Darwati Darwati Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor
  • Rani Maharani Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor
  • Kindi Farabi Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor
  • Risyandi Anwar Herbal Medicine Research, Department of Pediatric Dentistry, Faculty of Dental Medicine, University of Muhammadiyah Semarang, Semarang
  • Sofa Fajriah Research Centre for Raw Materials for Medicine and Traditional Medicine, National Research and Innovation Agency (BRIN), Tangerang Selatan, Banten
  • Muhamad Nurul Azmi School of Chemical Sciences, Universiti Sains Malaysia, 11800 Minden,Penang
  • Yoshihito Shiono Department of Food, Life, and Environmental Science, Faculty of Agriculture,Yamagata University, Tsuruoka, Yamagata

Abstract

Sesquiterpenoids are derivatives of terpenoid compound that have a diverse skeleton and broad spectrum of biological activities, particularly anticancer activity. This research reported the isolation and elucidation structure of sesquiterpenoid from Chisocheton lasiocarpus stem bark, as well as their cytotoxic activity. Four sesquiterpenoid compounds, namely eudesm-4(15)-ene-1β,6β-diol (1), allo-aromadendrane-10α,14-diol (2), allo-aromadendrane-10β,14-diol (3) and guaianediol (4), were isolated for the first time from Chisocheton lasiocarpus stem bark. The chemical structure of all compounds was identified by spectroscopic analysis, including IR, MS, 1H-NMR, 13C-NMR and DEPT, and compared with previous reported spectral data. The cytotoxic activity of the isolated compounds against MCF-7 breast cancer line were examined by using the resazurin method. The results showed compound 1 shown the highest cytotoxic activity with IC50 108.08 ± 0.58 µM.

Published
2022-11-19
How to Cite
SUPRATMAN, Unang et al. Sesquiterpenoids from Stem Bark of Chisocheton lasiocarpus and Their Cytotoxic Activity against MCF-7 Breast Cancer Cell. Molekul, [S.l.], v. 17, n. 3, p. 413-420, nov. 2022. ISSN 2503-0310. Available at: <http://jos.unsoed.ac.id/index.php/jm/article/view/6425>. Date accessed: 03 dec. 2022. doi: https://doi.org/10.20884/1.jm.2022.17.3.6425.
Section
Articles

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