The Effect of Giving Ciplukan (Physalis angulata L.) Extract on Serum Albumin Levels of Diabetes Model Rats

Abstract

Background : Diabetes mellitus is a chronic metabolic disease that frequently leads to microvascular complications, including diabetic nephropathy. This condition is characterized by renal damage that increases urinary albumin loss, which subsequently affects serum albumin levels. Physalis angulata L. is known to possess antioxidant, anti-inflammatory, and antifibrotic properties. Objective : This study aimed to determine the effect of Physalis angulata L. extract at doses of 75 mg/kgBW, 150 mg/kgBW, and 300 mg/kgBW on serum albumin levels in a diabetic rat model. Methodology : This study used stored biological materials in the form of serum samples obtained from a previous experimental study involving male Wistar rats. Diabetes had been induced using STZ-NA, and the rats had been divided into five groups: a healthy control group, a diabetic control group, and three diabetic groups receiving Physalis angulata L. extract at doses of 75 mg/kgBW, 150 mg/kgBW, and 300 mg/kgBW. Serum albumin levels were measured using the Bromocresol Green method. Data analysis was performed using Welch ANOVA. Results : The results show that serum albumin levels in the healthy control group, diabetic control group, and treatment groups remain within the normal range of 3.0-5.0 g/dL. Welch ANOVA indicates no statistically significant difference in serum albumin levels among the groups with p-value=0.496 (p > 0.05). Conclusion : In conclusion, administration of Physalis angulata L. extract at doses of 75 mg/kgBW, 150 mg/kgBW, and 300 mg/kgBW does not affect serum albumin levels in diabetic rats.