POTENSI EKSTRAK JINTAN HITAM (Nigella sativa) SEBAGAI KANDIDAT TERAPI KOMPLEMENTER DIABETES MELITUS
Abstract
Diabetes melitus merupakan penyakit metabolik dengan peningkatan glukosa dalam darah dengan ketidakmampuan sel β pankreas menghasilkan insulin maupun penurunan efektivitas penggunaan insulin. Perawatan utama Diabetes Melitus (DM) adalah terapi konvensional dengan menggunakan obat hipoglikemik oral dan terapi injeksi insulin. Masyarakat juga menggunakan pengobatan tradisional karena dianggap memiliki efek samping minimal. Jintan hitam (Nigella sativa) merupakan salah satu tanaman herbal yang dapat digunakan untuk menurunkan kadar gula darah. Penelitian ini bertujuan untuk mengetahui potensi manfaat dan dosis yang digunakan pada pengobatan diabetes melitus. Literature review ini diperoleh dengan hasil pencarian literatur melalui Pubmed dan Sciencedirect didapatkan 7(tujuh) jurnal penelitian eksperimental. Pemberian ekstrak jintan hitam (Nigella sativa) pada pasien diabetes melitus dapat menurunkan gula darah dengan efek hipoglikemik yang dimiliki dan sebanding dengan penggunaan metformin.
Kata kunci: diabetes melitus, metformin, Nigella sativa
References
Abraham, A. O., 2019. Antimicrobial Activity of N-Hexane Extract of Nigella Sativa against Some Pathogenic Bacteria. American Journal of Biomedical Science & Research. 6(5), pp.430–434.
Aljabre, S. H. M., Alakloby, O.M., & Randhawa, M.A., 2015. Dermatological Effects of Nigella sativa. Journal of Dermatology & Dermatologic Surgery. 19(2), pp.92–98.
Al Jamal, A. 2019. Effects of Nigella sativa and Metformin on HbA1C, Glucose tolerance and Lipid Profile of Diabetic Rats. Journal of Chemical and Pharmaceutical Sciences. 12(1): 6-9.
Asmat, U., Abad, K., & Ismail, K. 2016. Diabetes Mellitus and Oxidative Stress-A Concise Review. Saudi Pharmaceutical Journal. 24(5), 547–553.
Bashir, K. M. I., Kim, J. W., Kim, J. K., Chun, Y. S., Choi, J. S., Ku, S. K.
2023. Efficacy Confirmation Test of Black Cumin (Nigella sativa L.) Seeds Extract Using a High-Fat Diet Mouse Model. Metabolites. 13(4): 1-22.
Blair M. 2016. Diabetes Mellitus Review. Urologic Nursing. 36(1), 27–36.
Kesehatan Medika Saintika. 12(02): 305-313.
Dwita, L. P., Yati, K., & Gantini, S. N. (2019). The anti-inflammatory activity of nigella sativa balm sticks. Scientia Pharmaceutica. 87(1).
El-Naggar, T., Gómez-Serranillos, M. P., Palomino, O. M., Arce, C., & Carretero, M.E., 2010. Nigella sativa L. Seed Extract Modulates the Neurotransmitter Amino Acids Release in Cultured Neurons in Vitro. Journal of Biomedicine and Biotechnology. 2010.
Febriyanto, H., Herlina, A., Ibrahim. 2021. Hubungan Pola Makan dan Kegiatan Fisik dengan Perawatan Komplikasi Diabetes Melitus. Jurnal Kesehatan Medika Saintika. 12(02): 305-313.
Hardianto, D. 2020. Telaah Komprehensif Diabetes Melitus: Klasifikasi, Gejala, Diagnosis, Pencegahan, dan Pengobatan. Jurnal Bioteknologi & Biosains Indonesia. 7(2): 304-317.
Hassan, M.Q., Akhtar, M., Ahmed, S., Ahmad, A., & Najmi, A.K., 2017. Nigella sativa Protects Against Isoproterenol-induced Myocardial Infarction by Alleviating Oxidative Stress, Biochemical Alterations and Histological Damage. Asian Pacific Journal of Tropical Biomedicine. 7(4), pp.294–299.
Kemenkes RI. 2022. Diabetes Mellitus Tipe 2. Diakses pada 9 Desember 2023 di https://yankes.kemkes.go.id/view_artikel/1861/diabetes- mellitus-tipe- 2#:~:text=Diabetes%20mellitus%20adalah%20kondisi%20kronis,d apat%20menggunakan%20insulin%20secara%20efektif.
Kooshki, A., Tofighiyan, T., Rastgoo, N., Rakhshani, M. H., Miri, M. 2020. Effect of Nigella sativa oil supplement on risk factors for cardiovascular diseases in patients with type 2 diabetes mellitus. Phytotherapy Research. 34(10) :1-6.
Mohammed, S.J., Amin, H.H.H., Aziz, S.B., Sha, A.M., Hassan, S., Abdul Aziz, J.M., & Rahman, H.S., 2019. Structural Characterization, Antimicrobial Activity, and in Vitro Cytotoxicity Effect of Black Seed Oil. Evidence-Based Complementary and Alternative Medicine. 2019.
Mostafa, T. M., Hegazy, S. K., Elnaidany, S. S., Shehabeldin, W. A., Sawan,
E. S. 2021. Nigella sativa as a promising intervention for metabolic and inflammatory disorders in obese prediabetic subjects: A comparative study of Nigella sativa versus both lifestyle modification and metformin. Journal of Diabetes and Its Complications. 35 (2021): 1-10.
Pandiangan, A. and Ginting, K. P. 2019.Pemberian Ekstrak Biji Jintan Hitam pada Diabetes Melitus Tipe 2 sebagai Terapi. Jurnal Farmasetis. 8(2). pp. 67–74. doi: 10.32583/farmasetis.v8i2.618.
Pang, G. M., Li, F. X., Yan, Y., Zhang, Y., Kong, L. L., Zhu, P., Wang, K. F., Zhang, F., Liu, B., & Lu, C. (2019). Herbal Medicine in The Treatment of Patients with Type 2 Diabetes Mellitus. Chinese Medical Journal. 132(1): 78–85.
PERKENI. 2021. Pedoman Pengelolaan dan Pencegahan Diabetes Melitus Tipe 2 di Indonesia. PB Perkeni, Jakarta.
Ramalingam, K., Kuttan, R., Sivadasan, S. D., Ittiyavirah, S., Madhavamenon, K. I. 2021. Safety Assessment of a Thymoquinone- rich Black Cumin Oil (BlaQmax®): Acute and Sub-chronic Toxicity Studies. Journal of Nutrition & Food Sciences. 11(811): 1-8.
Rashwan, H. K., Mahgoub, S., Abuelezz, N. Z., Amin, H. K. 2023. Black Cumin Seed (Nigella sativa) in Inflammatory Disorders: Therapeutic Potential and Promising Molecular Mechanisms. Drugs Drug Candidates. 2(2): 516–537.
Rezeki, I.N. 2019. Peran Jintan Hitam (Nigella sativa) sebagai Pengobatan Diabetes Melitus. Jurnal Ilmiah Kesehatan Sandi Husada. 10(2): 255-260.
Sadiq, N., Subhani, G. & Fatima, S.A. 2021. Antidiabetic effect of Nigella sativa compared with metformin on blood glucose levels in streptozotocin induced diabetic albino wistar rats. International Journal of Basic & Clinical Pharmacology. 10(4): 361–367.
Srinivasan, K. 2018. Cumin (Cuminum cyminum) and black cumin (Nigella sativa) seeds: traditional uses, chemical constituents, and nutraceutical effects. Food Quality and Safety. 2(1): 1-16.
Stumvoll, M., Goldstein, B. J., & van Haeften, T. W. 2005. Type 2 Diabetes: Principles Of Pathogenesis and Therapy. Lancet. 365(9467), 1333– 1346.
Suryasa, W., Rodríguez-Gámez, M., & Koldoris, T. 2021. Health and treatment of diabetes mellitus. International journal of health sciences. 5(1): 1-5.
Susilawati, N. L. P. A., Cahyaningrum, P. L., Wiryanatha, I. B. 2021. Pemanfaatan Tanaman Obat untuk Mengatasi Penyakit Diabetes Melitus di Kota Denpasar. Jurnal Widya Kesehatan. 3(2): 1-7.
Taufik, I. 2020. Penggunaan Klinis Substansi Bioaktif Nigella sativa (Jintan Hitam) sebagai Alternatif Pengobatan Diabetes Mellitus Tipe 2. Majority. 9(02): 107-110.
Thomas, J. V., Mohan, M.E., Prabhakaran, P., Das S, S., Maliakel, B., Krishnakumar, I.M. 2022. A phase I clinical trial to evaluate the safety of thymoquinone-rich black cumin oil (BlaQmax®) on healthy subjects: Randomized, double-blinded, placebo-controlled prospective study. Toxicology Reports. 9 (2022): 999–1007.
Tiji, S., Benayad, O., Berrabah, M., Mounsi, I. E., Mimouni, M. 2021. Phytochemical Profile and Antioxidant Activity of Nigella sativa L Growing in Morocco. The Scientific World Journal. Vol 2021: 1-12. Wahyuni, S.D., Amalia, N., Murti, B. 2023. Penyuluhan Hipertensi dan Diabetes Melitus pada Lansia di RW 12 Jebres, Surakarta. Jurnal
Pengabdian Komunitas. 2(02): 70-76.
Aljabre, S. H. M., Alakloby, O.M., & Randhawa, M.A., 2015. Dermatological Effects of Nigella sativa. Journal of Dermatology & Dermatologic Surgery. 19(2), pp.92–98.
Al Jamal, A. 2019. Effects of Nigella sativa and Metformin on HbA1C, Glucose tolerance and Lipid Profile of Diabetic Rats. Journal of Chemical and Pharmaceutical Sciences. 12(1): 6-9.
Asmat, U., Abad, K., & Ismail, K. 2016. Diabetes Mellitus and Oxidative Stress-A Concise Review. Saudi Pharmaceutical Journal. 24(5), 547–553.
Bashir, K. M. I., Kim, J. W., Kim, J. K., Chun, Y. S., Choi, J. S., Ku, S. K.
2023. Efficacy Confirmation Test of Black Cumin (Nigella sativa L.) Seeds Extract Using a High-Fat Diet Mouse Model. Metabolites. 13(4): 1-22.
Blair M. 2016. Diabetes Mellitus Review. Urologic Nursing. 36(1), 27–36.
Kesehatan Medika Saintika. 12(02): 305-313.
Dwita, L. P., Yati, K., & Gantini, S. N. (2019). The anti-inflammatory activity of nigella sativa balm sticks. Scientia Pharmaceutica. 87(1).
El-Naggar, T., Gómez-Serranillos, M. P., Palomino, O. M., Arce, C., & Carretero, M.E., 2010. Nigella sativa L. Seed Extract Modulates the Neurotransmitter Amino Acids Release in Cultured Neurons in Vitro. Journal of Biomedicine and Biotechnology. 2010.
Febriyanto, H., Herlina, A., Ibrahim. 2021. Hubungan Pola Makan dan Kegiatan Fisik dengan Perawatan Komplikasi Diabetes Melitus. Jurnal Kesehatan Medika Saintika. 12(02): 305-313.
Hardianto, D. 2020. Telaah Komprehensif Diabetes Melitus: Klasifikasi, Gejala, Diagnosis, Pencegahan, dan Pengobatan. Jurnal Bioteknologi & Biosains Indonesia. 7(2): 304-317.
Hassan, M.Q., Akhtar, M., Ahmed, S., Ahmad, A., & Najmi, A.K., 2017. Nigella sativa Protects Against Isoproterenol-induced Myocardial Infarction by Alleviating Oxidative Stress, Biochemical Alterations and Histological Damage. Asian Pacific Journal of Tropical Biomedicine. 7(4), pp.294–299.
Kemenkes RI. 2022. Diabetes Mellitus Tipe 2. Diakses pada 9 Desember 2023 di https://yankes.kemkes.go.id/view_artikel/1861/diabetes- mellitus-tipe- 2#:~:text=Diabetes%20mellitus%20adalah%20kondisi%20kronis,d apat%20menggunakan%20insulin%20secara%20efektif.
Kooshki, A., Tofighiyan, T., Rastgoo, N., Rakhshani, M. H., Miri, M. 2020. Effect of Nigella sativa oil supplement on risk factors for cardiovascular diseases in patients with type 2 diabetes mellitus. Phytotherapy Research. 34(10) :1-6.
Mohammed, S.J., Amin, H.H.H., Aziz, S.B., Sha, A.M., Hassan, S., Abdul Aziz, J.M., & Rahman, H.S., 2019. Structural Characterization, Antimicrobial Activity, and in Vitro Cytotoxicity Effect of Black Seed Oil. Evidence-Based Complementary and Alternative Medicine. 2019.
Mostafa, T. M., Hegazy, S. K., Elnaidany, S. S., Shehabeldin, W. A., Sawan,
E. S. 2021. Nigella sativa as a promising intervention for metabolic and inflammatory disorders in obese prediabetic subjects: A comparative study of Nigella sativa versus both lifestyle modification and metformin. Journal of Diabetes and Its Complications. 35 (2021): 1-10.
Pandiangan, A. and Ginting, K. P. 2019.Pemberian Ekstrak Biji Jintan Hitam pada Diabetes Melitus Tipe 2 sebagai Terapi. Jurnal Farmasetis. 8(2). pp. 67–74. doi: 10.32583/farmasetis.v8i2.618.
Pang, G. M., Li, F. X., Yan, Y., Zhang, Y., Kong, L. L., Zhu, P., Wang, K. F., Zhang, F., Liu, B., & Lu, C. (2019). Herbal Medicine in The Treatment of Patients with Type 2 Diabetes Mellitus. Chinese Medical Journal. 132(1): 78–85.
PERKENI. 2021. Pedoman Pengelolaan dan Pencegahan Diabetes Melitus Tipe 2 di Indonesia. PB Perkeni, Jakarta.
Ramalingam, K., Kuttan, R., Sivadasan, S. D., Ittiyavirah, S., Madhavamenon, K. I. 2021. Safety Assessment of a Thymoquinone- rich Black Cumin Oil (BlaQmax®): Acute and Sub-chronic Toxicity Studies. Journal of Nutrition & Food Sciences. 11(811): 1-8.
Rashwan, H. K., Mahgoub, S., Abuelezz, N. Z., Amin, H. K. 2023. Black Cumin Seed (Nigella sativa) in Inflammatory Disorders: Therapeutic Potential and Promising Molecular Mechanisms. Drugs Drug Candidates. 2(2): 516–537.
Rezeki, I.N. 2019. Peran Jintan Hitam (Nigella sativa) sebagai Pengobatan Diabetes Melitus. Jurnal Ilmiah Kesehatan Sandi Husada. 10(2): 255-260.
Sadiq, N., Subhani, G. & Fatima, S.A. 2021. Antidiabetic effect of Nigella sativa compared with metformin on blood glucose levels in streptozotocin induced diabetic albino wistar rats. International Journal of Basic & Clinical Pharmacology. 10(4): 361–367.
Srinivasan, K. 2018. Cumin (Cuminum cyminum) and black cumin (Nigella sativa) seeds: traditional uses, chemical constituents, and nutraceutical effects. Food Quality and Safety. 2(1): 1-16.
Stumvoll, M., Goldstein, B. J., & van Haeften, T. W. 2005. Type 2 Diabetes: Principles Of Pathogenesis and Therapy. Lancet. 365(9467), 1333– 1346.
Suryasa, W., Rodríguez-Gámez, M., & Koldoris, T. 2021. Health and treatment of diabetes mellitus. International journal of health sciences. 5(1): 1-5.
Susilawati, N. L. P. A., Cahyaningrum, P. L., Wiryanatha, I. B. 2021. Pemanfaatan Tanaman Obat untuk Mengatasi Penyakit Diabetes Melitus di Kota Denpasar. Jurnal Widya Kesehatan. 3(2): 1-7.
Taufik, I. 2020. Penggunaan Klinis Substansi Bioaktif Nigella sativa (Jintan Hitam) sebagai Alternatif Pengobatan Diabetes Mellitus Tipe 2. Majority. 9(02): 107-110.
Thomas, J. V., Mohan, M.E., Prabhakaran, P., Das S, S., Maliakel, B., Krishnakumar, I.M. 2022. A phase I clinical trial to evaluate the safety of thymoquinone-rich black cumin oil (BlaQmax®) on healthy subjects: Randomized, double-blinded, placebo-controlled prospective study. Toxicology Reports. 9 (2022): 999–1007.
Tiji, S., Benayad, O., Berrabah, M., Mounsi, I. E., Mimouni, M. 2021. Phytochemical Profile and Antioxidant Activity of Nigella sativa L Growing in Morocco. The Scientific World Journal. Vol 2021: 1-12. Wahyuni, S.D., Amalia, N., Murti, B. 2023. Penyuluhan Hipertensi dan Diabetes Melitus pada Lansia di RW 12 Jebres, Surakarta. Jurnal
Pengabdian Komunitas. 2(02): 70-76.
Published
2024-05-25
How to Cite
FARY, Kevin Zufaris et al.
POTENSI EKSTRAK JINTAN HITAM (Nigella sativa) SEBAGAI KANDIDAT TERAPI KOMPLEMENTER DIABETES MELITUS.
Mandala Of Health, [S.l.], v. 17, n. 1, p. 60-72, may 2024.
ISSN 2615-6954.
Available at: <https://jos.unsoed.ac.id/index.php/mandala/article/view/10958>. Date accessed: 27 apr. 2025.
doi: https://doi.org/10.20884/1.mandala.2024.17.1.10958.
Section
Articles
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
