Antioxidant Activity of Stannous Complexes Containing Amide Functionality

  • Raji Thomas St. Martin's Engineering College, Hyderabad
  • Pushpa Pardasani
DOI: https://doi.org/10.20884/1.jm.2026.21.1.14935

Abstract

ABSTRACT. Oxidative stress induced by free radicals is closely associated with aging and various degenerative diseases, prompting the search for efficient antioxidant systems. Metal chelation is known to enhance the biological activity of organic ligands by altering their electronic and redox characteristics. In this study, penta- and tetra-coordinated stannyl complexes of N,N′-bis(2-pyridyl)pyridine-2,6-dicarboxamide (H₂L₁) and N-(pyridine-2-yl)picolinamide (HL₂) were synthesized and evaluated for their antioxidant activity using the DPPH free radical scavenging assay. Penta and tetra coordinated stannyl derivatives of N, N'-Bis(2-pyridyl)pyridine-2,6-dicarboxamide (H2L1) and N-(pyridine-2-yl)picolinamide (HL2) have been synthesized by the reported procedure and selected for the antioxidant studies. The free radical scavenging activity of ligands and the metal complexes have been analyzed by means of their interaction with stable free radical 1, 1-diphenyl-2-picrylhydrazyl (DPPH). The molecular structures and electronic properties of complexes and the mechanism involved in the scavenging activity were well analyzed by GAUSSIAN 03 suit of programs.


 


Keywords: Amide complexes, computational,  DPPH, free radical

Published
2026-04-01
How to Cite
THOMAS, Raji; PARDASANI, Pushpa. Antioxidant Activity of Stannous Complexes Containing Amide Functionality. Molekul, [S.l.], v. 21, n. 1, p. 94-101, apr. 2026. ISSN 2503-0310. Available at: <https://jos.unsoed.ac.id/index.php/jm/article/view/14935>. Date accessed: 14 apr. 2026. doi: https://doi.org/10.20884/1.jm.2026.21.1.14935.
Citation Formats
Issue
Vol 21 No 1 (2026)
Section
Theoretical and Environmental Chemistry

Authors agree with the statements below:

  1. Authors automatically transfer the copyright to the MOLEKUL journal and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
  2. Authors are able to enter into separate permission for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.