Preparation of Atorvastatin Calcium-Dipicolinic Acid Multicomponent Solids by Liquid-Assisted Grinding Method to Increase Solubility

  • Yudi Wicaksono Faculty of Pharmacy, University of Jember
  • Shafira Faradiba Tsaniyah Active Pharmaceutical Ingredient and Excipient Research Group, Faculty of Pharmacy, University of Jember
  • Budipratiwi Wisudyaningsih Active Pharmaceutical Ingredient and Excipient Research Group, Faculty of Pharmacy, University of Jember
  • Kuni Zu''aimah Barikah Active Pharmaceutical Ingredient and Excipient Research Group, Faculty of Pharmacy, University of Jember
  • Lusia Oktora Ruma Kumala Sari Drug Delivery Research Group, Faculty of Pharmacy, University of Jember

Abstract

Atorvastatin calcium is a cholesterol-lowering drug that is very potent but difficult to dissolve in water, so its bioavailability is low. In this study, atorvastatin calcium-dipicolinic acid multicomponent solids were prepared using the liquid-assisted grinding method to improve atorvastatin calcium's solubility. Characterization of multicomponent solids was carried out using powder x-ray diffraction (PXRD), differential scanning calorimetry (DSC), fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). Solubility test was carried out by shaking method using distilled water media. The results showed that the particles of atorvastatin calcium - dipicolinic acid multicomponent solids had an irregular shape with rough and porous surface topography. The multicomponent solids have a diffractogram with specific peaks of 2θ at 8.8, 9.9, 11.5, 16.7, 19.1, 21.2, 22.4, 23.4, and 27.7°. The DSC thermogram of multicomponent solids showed a sharp endothermic peak at 181.9 °C (∆H=17.69 J/g), indicating its melting point. The FTIR spectra of atorvastatin calcium-dipicolinic acid multicomponent solids indicated an intermolecular interaction that was thought to be a hydrogen bond between the molecules of atorvastatin calcium and dipicolinic acid. The results of the solubility test showed that the atorvastatin calcium-dipicolinic acid multicomponent solids had a significantly increased solubility (p<0.05) compared to the solubility of pure atorvastatin calcium.

Author Biography

Shafira Faradiba Tsaniyah, Active Pharmaceutical Ingredient and Excipient Research Group, Faculty of Pharmacy, University of Jember

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Published
2022-11-19
How to Cite
WICAKSONO, Yudi et al. Preparation of Atorvastatin Calcium-Dipicolinic Acid Multicomponent Solids by Liquid-Assisted Grinding Method to Increase Solubility. Molekul, [S.l.], v. 17, n. 3, p. 365-372, nov. 2022. ISSN 2503-0310. Available at: <http://jos.unsoed.ac.id/index.php/jm/article/view/5946>. Date accessed: 02 dec. 2022. doi: https://doi.org/10.20884/1.jm.2022.17.3.5946.
Section
Articles