Analysis of Chemical Content, Cytotoxic and Anti-Bacterial Activity Essential Oil of Lantana Camara Linn Leaves from Various Regions

  • Suryati suryati Andalas University
  • Adlis Santoni Natural Materials Organic Chemistry Laboratory, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Andalas University
  • Bustanul Arifin Natural Materials Organic Chemistry Laboratory, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Andalas University
  • Norman Ferdinal Natural Materials Organic Chemistry Laboratory, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Andalas University
  • Emil Salim Natural Materials Organic Chemistry Laboratory, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Andalas University
  • Asri Amelia Natural Materials Organic Chemistry Laboratory, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Andalas University
  • Leidina Zein Natural Materials Organic Chemistry Laboratory, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Andalas University
  • Silfani Mairanti Natural Materials Organic Chemistry Laboratory, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Andalas University
  • Indah Putri Lestari Natural Materials Organic Chemistry Laboratory, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Andalas University

Abstract

Lantana camara Linn is a family of Verbenaceae that grows in tropical and subtropical areas and spread in about 50 countries in the world. This plant contains essential oils with different contents based on the difference in the place of growth. The purpose of this study was to isolate and determine the chemical content of the essential oil of L. camara Linn leaves obtained from Agam, Tanah Datar, Kampar Regency, Padang Panjang City and to determine its cytotoxic and antibacterial activity. Isolation was carried out by hydro distillation method and chemical content analysis using Gas Chromatography-Mass Spectrometry (GC-MS). The high yield from the isolation of essential oil from leaves of L. camara Linn obtained from Tanah Datar Regency was 0.095% (w/w). The results of the analysis of the essential oil content with the main compounds for all Regency and City being caryophyllene with the high area percent was Tanah Datar Regency (19.74%). Cytotoxic activity test using the Brine Shrimp Lethality Test (BSLT) method showed that L. camara Linn essential oil was highly toxic with an LC50 value of 28.34 µg/mL from Padang Panjang City. Antibacterial activity test by disc diffusion method showed that L. camara Linn essential oil had moderate antibacterial activity againts Staphylococcus aureus and Escherichia coli bacteria, with high clear zone from Agam Regency was 12.9 mm and Tanah Datar Regency was 7.8 mm, respectively, at concentration of 100%.

Published
2022-07-21
How to Cite
SURYATI, Suryati et al. Analysis of Chemical Content, Cytotoxic and Anti-Bacterial Activity Essential Oil of Lantana Camara Linn Leaves from Various Regions. Molekul, [S.l.], v. 17, n. 2, p. 156-164, july 2022. ISSN 2503-0310. Available at: <http://jos.unsoed.ac.id/index.php/jm/article/view/5143>. Date accessed: 03 dec. 2022. doi: https://doi.org/10.20884/1.jm.2022.17.2.5143.
Section
Articles