Therapeutic Effect of Hijamah (Cupping Therapy) on Lipid Profiles and Apolipoprotein in Hypercholesterolemic Patients


  • Ratna Pelawati
  • Wahyudi Widada Nursing School of Muhammadiyah University, Jember, East Java, Indonesia
  • Endah Wulandari Faculty Medicine, Islamic State University Syarif Hidayatullah Jakarta, Indonesia
  • Mardiyanti Mardiyanti UIN Syarif Hidayatullah Jakarta
  • Samsiah Samsiah School of nursing, Faculty of Health Science UIN Syarif Hidayatullah jakarta


Hijamah or cupping therapy has a therapeutic effect on cholesterol. However, there is still a lack of studies that investigate the potential effect of cupping in managing apolipoprotein B as a proatherogenic agent and apolipoprotein A-1 as an anti-proatherogenic agent. This study aims to explore the effect of cupping therapy on lipid profiles and apolipoproteins in hypercholesterolemic patients. A pre-post experimental design without controls were used. Consecutive sampling was applied to 40 dyslipidemia respondents. The lipid profiles and plasma apolipoproteins A-I (ApoA-I) and apolipoproteins B (ApoB) were measured after the respondents fasted for 12 hours before cupping therapy and 24 hours after cupping therapy. The Wilcoxon sign-rank test was used for the data analysis. The following results were found: average lipid profile (mg/dL) and apolipoprotein (µg/mL) pre vs post cupping: Total Cholesterol (Pre-test vs Post-test) 328 vs 283 (P-value 0.003); TG 238 vs 204 (P- value 0.007); HDL 78.5 vs 85 (P- value 0.000); LDL 195 vs 158 (P- value 0.001); ApoA-1 0.07 vs 0.67 (P-value 0.000); ApoB 2.04 vs 1.82 (P-value 1.000); ApoB/ApoA-1 ratio 30.22 vs 2.93 (P- value 0.000); cholesterol/HDL ratio 4.06 vs 3.08 (P- value 0.332); TG/HDL ratio 3.01 vs 2.83 (P- value 0.104); LDL/ApoB ratio 90.75 vs 83.82 (P- value 0.0837). In conclusion, cupping therapy reduces total cholesterol, TG, LDL, and apoB/ApoA-1 ratio and increases HDL significantly in dyslipidemic patients. Nurses are suggested to include cupping therapy (hijamah) in their intervention for reducing hypercholesterolemia in dyslipidemic patients.

How to Cite
PELAWATI, Ratna et al. Therapeutic Effect of Hijamah (Cupping Therapy) on Lipid Profiles and Apolipoprotein in Hypercholesterolemic Patients. Jurnal Keperawatan Soedirman, [S.l.], v. 17, n. 2, p. 81-86, july 2022. ISSN 2579-9320. Available at: <>. Date accessed: 30 nov. 2022. doi: