Systematic Review: CD4 Increase in HIV/AIDS Patients
Abstract
Introduction: Acquired Immunodeficiency Syndrome (AIDS) is a collection of symptoms and infectious diseases caused by damage to the human immune system due to infection with the HIV (Human Immunodeficiency Virus). The type of CD4 T lymphocyte cell is the main target of the HIV virus in infecting the human body. The lower the number of CD4 T lymphocytes in the blood, the lower a person's immune system will be. Methods: The authors conducted an article search beginning on June 10 using research in an electronic database. The Identified Article is a research study that investigates CD4 cell elevation in HIV/AIDS patients. Systematic compilation begins with search databases on Google Scholar, PHPJ, PubMed. the method is based on a prismatic systematic guideline and is systematically reviewed. Discussion: The results of this study indicate that the more progressive the HIV infection in a person's body, the lower his CD4 level will be. A decrease in CD4 levels will be followed by a decrease in the number of lymphocytes, the ratio of lymphocytes to leukocytes, and the ratio of lymphocytes to neutrophils. This shows that the immune system of people infected with HIV is decreasing. Conclusion: The more severe the condition of people with HIV infection, the lower the CD4 count. Complete blood counts were performed automatically using Abbott Diagnostics' CELL-DYN Ruby Hematology Analyzer.
References
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25. Thigpen, M. C., Kebabetswe, P. M., & Paxton, L .A. (2012). Antiretroviral preexposure prophylaxis for heterosexual HIV transmission in Botswana. N Engl J Med, 367(5), 423–34.
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28. Yasin, N. M., Maranty, H., & Ningsih, W. R. (2011). Analisis respon terapi antiretroviral pada pasien HIV/AIDS. Majalah Farmasi Indonesia, 22(3), 212- 222
29. Yogani, I., Karyadi, T. H., & Koesnoe,S. (2015). Faktor-faktor yang Berhubungan dengan Kenaikan CD4 pada Pasien HIV yang Mendapat Highly Active Antiretroviral Therapy dalam 6 bulan Pertama. Jurnal Penyakit Dalam Indonesia. 2(4), 217-222
30. Yuliandra, Y., Nosa, U. S., Raveinal., & Almasdy, D. (2017). Terapi Antiretroviral pada Pasien HIV/AIDS di RSUP. Dr. M. Djamil Padang: Kajian Sosiodemografi dan Evaluasi Obat. Jurnal Sains Farmasi & Klinis, 4(1), 1-8.
31. Yuki Steven A, Kaiser Phillipp, dkk. 2018. HIV Latency in Isolated Patient CD4+ t Cells May be Due to Blocks in HIV Transcriptional elongation, comletion, an splicing. San Fransisco
32. Zhang, Gang. 2020. CD4+ T Cell- Mimicking Nanoparticles Broadly Neutralize HIV-1 and Suppress Viral Replication Through Autophagy. Available at: https://www.ncbi.nlm.nih.gov/pmc/artic les/PMC7492730/ (Accessed: 12 June 2022).
33. Zipursky, A. R., Gogolishvili, D., Rueda, S., Brunetta, J., Carvalhal, A., McCombe, J. A., & Rourke, S. B. (2013). Evoluation of brief screening tools for neurocognitive imparment in HIV/AIDS. AIDS, 27(15), 2385-2401
2. Aptriani, R., Fridayenti & Barus, A., 2014. GAMBARAN JUMLAH CD4 PADA PASIEN HIV/AIDS. Jom FK, I(2), pp. 1-12.
3. Aurelina, R. 2020. Faktor-faktor yang berhubungan terhadap kadar cluster of differentiation 4 (cd4) pada pasien hiv/aids. JMH (Jurnal Medika Hutama) Vol 02 No 01.
4. Bhatti, A. B., Usman, M., & Venkataramana, K. (2015). Current Scenario of HIV/AID, Treatment Option, and Major Challenges with Compliance to Antiretroviral Therapy. Cureus, 8(3), 515.
5. Boniphace, I., Minzi, O., Rumisha S. F., & Mugus F., & Tanner M. (2011). HIV/AIDS Clinical Manifestations and the Implication for Patient Clinical Staging in Resource Limited Settings in Tanzania. The Open AIDS Journal, 5(4), 9-16.
6. Chalker, J. C., Anddualem, T., Gitau, L. N., Ntaganira, J., Obua, C., Tadeg, H., Waako, P., Degnan, D. F. (2010). Measuring adherence to antiretroviral treatment in resource-poor settings: The feasibility of collecting routine data for key indicators. BMC Health Services Research, 10(1), 34-37.
7. Chatterjee, Supantha, dkk. 2016. Quality of Life of HIV/AIDS Patients: The Influence of CD4 Count on It. National Journal of Community Medicine.
8. Fajar, E. P. P. (2013). Hubungan Antara Stadium Klinis, Viral Load Dan Jumlah CD4 Pada Pasien Human Immunodeficiency Virus (HIV) / Acquired Immuno Deficiency Syndrome (AIDS) Di RSUP Dr. Kariadi Semarang. Jurnal Media Medika Muda, 3(5), 1-12
9. Fevrier, M., Dorgham, K., & Rebollo, A. (2017). CD4+ T Cell Depletion in Human Immunodeficiency Virus (HIV) Infection: Role of Apoptosis. Jurnal Viruses, 3(2), 586-612
10. Gowda, S, Channabasappa, AN, Dhar, M, & Krishna, D. 2012. Quality of life in HIV/AIDS patients in relation to CD4 count: A cross sectional study in Mysore district. International Journal of Health & Allied Sciences Vol. 1. Issue 4. Oct- Dec 2012
11. Hutapea, H. M. L., Mirino, Y., Widiyanti, M., Fitriana, E., Maladan, Y., & Oktavian, A. (2017). Penurunan CD4 Pada ODHA Setelah Terapi ARV Lebih Dari 39 Bulan. The Indonesia Journal of Public Health, 13(3).
12. Ibrahim, K, H Kurnia, Y, Rahayuwati, L, Nurmalisa, BE, Fitri, S,U,R. 2017. Hubungan antara Fatigue, Jumlah CD4, dan Kadar Hemoglobin pada Pasien yang Terinfeksi Human Immunodeficiency Virus (HIV). JKP - Volume 5 Nomor 3.
13. Keputusan Menteri Kesehatan Republik Indonesia, (2011). Tentang Rumah Sakit Rujukan Bagi Orang Dengan HIV dan AIDS No. 782 Tahun 2011. Jakarta: Menteri Kesehatan.
14. Kurniawan, F., Djauzi, S., Yunihastuti, E., & Nugroho, P. (2017). Faktor Prediktor Kegagalan Virologis Pada Pasien HIV Yang Mendapatkan Terpai ARV Lini Pertama Dengan Kepatuhan Berobat Baik. Jurnal Penyakt Dalam Indonesia, 4(1), 29-34
15. Ladyani Festy, Kristianingsih Anisa. 2016. Hubungan Antara Jumlah CD4 Pada Pasien Yang Terinfeksi HIV/AIDS Dengan Infeksi Oportunistik di Rumah Sakit Umm Abdul Moeloek Bandar Lampung Tahun 2016. Fakultas Kedokteran Malahayati.
16. Levine, D., Madsen, A., Wright, E., Barar R. E, Santelli J, & Bull S. (2011). Formative research on MySpace: online methods to engage hard-to-reach populations. Journal of health communication, 16(4), 448-54.
17. Manuaba, I. A. K. W., & Yasa, I. W. P. S. (2017). Tingkat Kepatuhan Mengkonsumsi Obat Antiretroviral Dengan Jumlah CD4 Pada Pssien HIV/AIDS Di Klinik VCT RSUP Sanglah Dalam Periode September- November 2014. E-Jurnal Medika, 6(1), 2303-1395
18. Menteri Kesehatan, (2014). Peraturan Menteri Kesehatan Republik Indonesia nomor 87 Tahun 2014 tentang Pedoman Pengobatan Antiretroviral. Jakarta: Menteri Kesehatan
19. Metry, Ashwini, Jairaj Bhaskar and Shantkumari. 2021. A study on correlation between blood parameters and CD4 count in people living with HIV/AIDS. International Journal of Advanced Research in Medicine
20. Nurmawati, T., Sari, Y. K. & Hidayat, A. P., 2019. The relationship between length of treatment and CD4 cell count in HIV/AIDS sufferers who run the antiretroviral treatment program (ARV). Jurnal Ners dan Kebidanan, VI(2), pp. 197-202.
21. Pettifor, A., Linda, G. B., Sybil, H., Molly, R., & Seana, B. (2013). Preventing HIV among Young People: research priorities for the future. J Acquir Immune Def Syndr, 2, 155-S160.
22. Purnama, S. (2010). Karakteristik penderita HIV/AIDS di Puskesmas Tanjung Morawa Agustus 2006 – Mei 2010. Medan. Tesis Fakultas Kesehatan Masyarakat Universitas Sumatra Utara.
23. Salwe, Sukeshani. 2019. Immune Signatures for HIV-1 and HIV-2 Induced CD+T Cell Dysregulation In An Indian Cohort. Available at: https://www.ncbi.nlm.nih.gov/pmc/artic les/PMC6371624/ (Accessed: 12 June 2022).
24. Tegegne, Awoke Seyoum. 2021. Predictors associated with the variation of CD4 cell count and body mass index (BMI) for HIV positive adults under ART. Scientific African. Bahir Dar University: Ethiopia
25. Thigpen, M. C., Kebabetswe, P. M., & Paxton, L .A. (2012). Antiretroviral preexposure prophylaxis for heterosexual HIV transmission in Botswana. N Engl J Med, 367(5), 423–34.
26. Valdivia, A., Ly, J., Gonzalez, L., Hussain, P., Saing, T., Islamoglu, H., Pearce, D., Ochoa, C., & Venketaraman, V. (2017). Restoring Cytokine Balance in HIV-Positive Individuals with Low CD4 T Cell Counts. Aids Research and Human Retroviruses, 33(9), 905-918
27. World Health Organization, (2016). Consolidated guideline on the use of antiretroviral drugs for treating and preventing HIV infection 2nd ed.Geneva: World Health Organization, 91- 154.
28. Yasin, N. M., Maranty, H., & Ningsih, W. R. (2011). Analisis respon terapi antiretroviral pada pasien HIV/AIDS. Majalah Farmasi Indonesia, 22(3), 212- 222
29. Yogani, I., Karyadi, T. H., & Koesnoe,S. (2015). Faktor-faktor yang Berhubungan dengan Kenaikan CD4 pada Pasien HIV yang Mendapat Highly Active Antiretroviral Therapy dalam 6 bulan Pertama. Jurnal Penyakit Dalam Indonesia. 2(4), 217-222
30. Yuliandra, Y., Nosa, U. S., Raveinal., & Almasdy, D. (2017). Terapi Antiretroviral pada Pasien HIV/AIDS di RSUP. Dr. M. Djamil Padang: Kajian Sosiodemografi dan Evaluasi Obat. Jurnal Sains Farmasi & Klinis, 4(1), 1-8.
31. Yuki Steven A, Kaiser Phillipp, dkk. 2018. HIV Latency in Isolated Patient CD4+ t Cells May be Due to Blocks in HIV Transcriptional elongation, comletion, an splicing. San Fransisco
32. Zhang, Gang. 2020. CD4+ T Cell- Mimicking Nanoparticles Broadly Neutralize HIV-1 and Suppress Viral Replication Through Autophagy. Available at: https://www.ncbi.nlm.nih.gov/pmc/artic les/PMC7492730/ (Accessed: 12 June 2022).
33. Zipursky, A. R., Gogolishvili, D., Rueda, S., Brunetta, J., Carvalhal, A., McCombe, J. A., & Rourke, S. B. (2013). Evoluation of brief screening tools for neurocognitive imparment in HIV/AIDS. AIDS, 27(15), 2385-2401
Published
2023-03-28
How to Cite
HIDAYAT, Arif Imam.
Systematic Review: CD4 Increase in HIV/AIDS Patients.
International Journal of Biomedical Nursing Review, [S.l.], v. 2, n. 1, p. 132-136, mar. 2023.
ISSN 2962-4703.
Available at: <http://jos.unsoed.ac.id/index.php/ijbnr/article/view/8376>. Date accessed: 27 apr. 2024.
doi: https://doi.org/10.20884/1.ijbnr.2022.1.2.8376.
Section
Articles
Kampus keperawatan unsoed 
