RISK FACTORS ASSOCIATED WITH THE EVENT OF PROSTATE CANCER (CASE STUDY IN Prof. Dr. MARGONO SOEKARJO PURWOKERTO HOSPITAL)

  • Viva Ratih Bening Ati Medical faculty of Jenderal Soedirman

Abstract

The incidence of prostate cancer (PCa) is closely related to increasing age and other factors such as family history, obesity, smoking habits, vasectomy history, and alcohol consumption. As the number of cases increases, understanding the risk factors associated with the incidence of PCa becomes very important. Therefore, this study was conducted to determine the risk factors for PCa in Prof. Dr. Margono Soekarjo Purwokerto’s Hospital as an approach to the identification and prevention of PCa events. Observational research using cased control was conducted at the Urology Surgery Polyclinic of Prof. Dr. Margono Soekarjo Purwokerto Hospital. 15 PCa patients and controls in the form of participants diagnosed with other cancers as many as 8 people. Univariate analysis using SPSS was conducted to determine the relationship of risk factors to the incidence of PCa with a significance of p<0.05. The results showed that some of the prominent characteristics of PCa respondents were age >60 years (66.7%), married (80%), not suffering from diabetes mellitus (93.3%), normal lifestyle (80%), and not consuming alcohol (100%). In the control group, age >60 years (62.5%), no family history of prostate cancer (100%), normal lifestyle (100%), and smoking (50%). From the results of the study, it was concluded that the characteristics of respondents in the case group were mostly aged > 60 years, had low education, worked as farmers, and had no history of prostate cancer in their family.

References

Algota, A.M., Stratton, S.P., Moore, J.R., et al. 2011. Association of obesity and smoking with PSA and PSA velocity in men with prostate cancer. Am J Men’s Health. 5:272-8.
Baade, P.D., Youlden, D.R., Cramb, S.M., Dunn, J., Gardinar, R.A. 2013. Epidemiology of prostate cancer in the Asia-pacific region. Prostate Int. 1:47-58.
Bashir, M.N., Ahmad, M.R, Malik, A. 2014. Risk Factors of Prostate Cancer: a Case-control Study in Faisalabad, Pakistan. Asian Pacific Journal of Cancer Prevention. Vol 15 (23). pg 10237-10240.
Bostwick, D.G, Burke, H.B, Djakiew, D., et al. 2004. Human Prostate Cancer Risk Factors. American Cancer Society. 101:10.
Clarry, C.N., Sandhika, W., Arwati, H. 2018. Hubungan antara Kadar Prostate Specific Antigen Serum dan Skor Gleason pada Adenokarsinoma Prostat. Jurnal Kedokteran Brawijaya Vol. 30, No. 3, pp. 181-184.
Cullen, J., Elsamanoudi, S., Brassel, S.A., Chen, Y., Colombo, M., Srivastava, A., McLeod, D.G. 2012. The Burden of Prostate Cancer in Asian Nations. Journal of Carcinogenesis: 61-9.
Giovannucci, E., Liu, Y., Platz, E.A., Stampfer, M., Willett, W.C. 2007. Risk factors for prostate cancer incidence and progression in the health professional’s follow-up study. Int J Cancer. 121:1571-8.
Globocan. 2008. International Agency for Research on Cancer. World Health Organization. Dapat diakses di: http://globocan.iarc.fr/factsheets/populations/factsheet.asp?uno=360.
Gong, Z., Agalliu, I., Lin, D.W., Stanford, J.L., Kristal, A.R. 2008. Cigarette smoking and prostate cancer-specific mortality following diagnosis in middle-aged men. Cancer Cause Control. 19:25-31.
Hsing, A.W., Deng, J., Sesterhenn, I.A., et al. 2000. Body size and prostate cancer: a population-based case-control study in China. Cancer Epidemiol Biomarkers Prev. 9: 133-41.
International Agency for Research on Cancer. 2012. Estimated cancer incidence, mortality and prevalence worldwide in 2012.
Lubis, Y.E.P., Raja, S.L. dan Suroto, R.B. 2018. Faktor-Faktor Risiko yang Berhubungan dengan Kejadian Kanker Prostat di Poliklinik Bedah Urologi RSUP H. Adam Malik Medan. PRIMER (Prima Medical Journal). Vol. 1 No. 1: 42-51.
Parkin, D.M., Brays, F., Ferlay, J. 2004. Global cancer statistics. Cancer J Clin. 55:74-108.
Perdana, R dan Chaidir A. 2016. The Risk Factors of Prostate Cancer and Its Prevention: A Literature Review. Department of Urology, Faculty of Medicine Universitas Indonesia.
Tambunan, N. dan Umbas, R. 2014. Peran Faktor Nutrisi pada Pencegahan Kanker Prostat. Indonesian Journal of Cancer. Vol. 8(3):135-140.
Tyagi, B., Manoharm, N., Raina, V. 2010. A case control study on prostate cancer in Delhi. Asian Pac J Cancer Prev. 11:397-401.
Willet, W.C., dan Giovannucci, E. 2006. Epidemiology of Diet and Cancer Risk. In: Shils ME, Shike M, Ross AC, Caballero B, Cousins RJ, editors. Modern Nutrition in Health and Disease. 10th ed. Philadelphia: Lippincott Williams and Wilkins:1267-79.
Xin, Z., Qi, W., Neil, B., dan Xiao, C. 2010. Effect of lycopene on androgen receptor and prostate-specific antigen velocity. Chinese Med Jour. 123(16):2231-36.
Zuccolo, L., Lewis S.J., Donovan, J.L., Hamdy, F.C., Neal, D.E., Smith G.D. 2012. Alcohol consumption and PSA-detected prostate cancer risk-a case-control nested in the protect study. Int J Cancer. 132(9):2176-1785.
Published
2021-12-23
How to Cite
ATI, Viva Ratih Bening. RISK FACTORS ASSOCIATED WITH THE EVENT OF PROSTATE CANCER (CASE STUDY IN Prof. Dr. MARGONO SOEKARJO PURWOKERTO HOSPITAL). Mandala Of Health, [S.l.], v. 14, n. 2, p. 67-73, dec. 2021. ISSN 2615-6954. Available at: <http://jos.unsoed.ac.id/index.php/mandala/article/view/5116>. Date accessed: 20 apr. 2024. doi: https://doi.org/10.20884/1.mandala.2021.14.2.5116.