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Diabetes mellitus is a metabolic disease characterized by chronic hyperglycemia. This high levels of blood glucose can lead both macro and microvascular complications. In addition to a great social impact, DM complications also determine age and quality of life of the patient. In order to prevent such complications, this research used nonpharmacological intervention with diet therapy, goat’s milk and soymilk based kefir, to restore blood glucose levels within normal range. The objective of this study was to determine the effect of goat’s milk and soy milk-based kefir on blood glucose levels rat model of DM type 2. This research was an experimental study, pre-posttest with control group design. The subjects were male Wistar rats, induced by streptozotocin-nicotinamide, treated with goat’s milk kefir, soy milk kefir and kefir combination of goat's milk and soy milk. Fasting Blood Glucose (FBG) plasma examined by enzymatic photometric method. Results showed that treatment with goat’s milk kefir, soy milk kefir and kefir combination of goat’s milk - soy milk can reduce FBG levels in DM type 2 rat model. Goat’s milk kefir and combination of goat’s milk - soy milk kefir can decrease the average of FBG levels significantly (p = 0.000), and effectively restore FBG levels within normal range.