• Ardhiana P
  • Atika R Department of Nutrition, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto
  • Riska Y Department of Nutrition, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto
  • Atikah Proverawati Department of Nutrition, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto


Introduction: Prostate cancer is cancer that develops in the prostate gland of the male reproductive system. It is caused by prostate cells that begin to mutate and multiply out of control. Prostate cancer is the most common cancer in men globally after lung cancer. Lycopene has been identified as an antioxidant substance that is potentially an anticancer substance. Lycopersicum is a carotenoid most commonly found in tomatoes (Solanum lycopersicum L.). However, some studies’ results for the relationship between lycopene in tomatoes (Solanum lycopersicum L.) with the risk of prostate cancer still show inconsistencies. Purpose: This study aims to find out and update the data related to the correlation between lycopene content in tomatoes and the risk of prostate cancer.  Methods: This research method uses a systematic review method by searching research journals from PubMed, Google Scholar, and Science Direct database with inclusion criteria for analysis.  Results: As a result, 6 out of 5 similar research journals for analyses related to the correlation between lycopene in tomatoes (Solanum lycopersicum L.) with a reduced risk of prostate cancer. Discussion: Prostate cancer patients have a low antioxidant content in their blood, thus increasing the stress of oxidation and lipid peroxidation. Reducing the risk of oxidation requires an intake of antioxidant substances that function as an anticancer substances, one of which is lycopene in tomatoes (Solanum lycopersicum L.). Lycopene serves as a free radical carcinogenesis substance and increases overall antioxidants, thereby reducing oxidative damage to lipids, proteins, and DNA. Although there are still inconsistencies in some studies related to the co-relationship of the two, this study concludes that there is a tendency to a correlation between lycopene in tomatoes (Solanum lycopersicum L.) with drop risk of prostate cancer. Conclusion: Thus, effective levels of lycopene in tomatoes (Solanum lycopersicum L.), which should be consumed at a certain time to lower the risk of prostate cancer are still unclear in number and more research is still needed related to this.


Adams, K. C. et al. (2004) ‘The growth of the Dunning R-3327-H transplantable prostate adenocarcinoma in rats fed diets containing tomato, broccoli, lycopene, or receiving finasteride treatment’, undefined.
Agarwal, S. and Rao, A. V (2000) ‘Tomato lycopene and its role in human health and chronic diseases.’, CMAJ : Canadian Medical Association journal = journal de l’Association medicale canadienne, 163(6), pp. 739–744.
Van Breemen, R. B. et al. (2011) ‘Antioxidant effects of lycopene in African American men with prostate cancer or benign prostate hyperplasia: A randomized, controlled trial’, Cancer Prevention Research, 4(5), pp. 711–718. doi: 10.1158/1940-6207.CAPR-10-0288.
Castillejos-molina, R. A. and Gabilondo-navarro, F.B. (2016) 'Prostate cancer', Mexico Public Health,58(2), pp. 279–284.
Chen, P. et al. (2015) ‘Lycopene and Risk of Prostate Cancer : A Systematic Review and Meta-Analysis’, Medicine, 94.
Febriansah, R., Indriyani, L. and Muthi, K. D. P. and (2016) 'Tomato ( Solanum lycopersicum L.) as Potenial Chemopreventive Agent', (May), pp. 1–8.
Gann, P. H. et al. (1999) ‘Lower prostate cancer risk in men with elevated plasma lycopene levels: Results of a prospective analysis’, Cancer Research, 59(6), pp. 1225–1230.
Grainger, E. M. et al. (2015) ‘A comparison of plasma and prostate lycopene in response to typical servings of tomato soup, sauce or juice in men before prostatectomy’, cambridge.org. doi: 10.1017/S0007114515002202.
Holzapfel, N. P. et al. (2013) ‘The Potential Role of Lycopene for the Prevention and Therapy of Prostate Cancer: From Molecular Mechanisms to Clinical Evidence.’, International journal of molecular sciences, 14(7), pp. 14620–14646. doi: 10.3390/ijms140714620.
Kailaku, S. I., Dewandari, K. T. and Sunarmani (2016) 'Lycopene Potential in Tomatoes for Health', Post-Harvest Technology Bulletin,3(1), pp. 50–58.
Decree of the Minister of Health of the Republic of Indonesia (2018) National Guidelines for Prostate Cancer Management MedicalServices, Health Research and Development Agency.
Kiciński, M., Vangronsveld, J. and Nawrot, T. S. (2011) ‘An epidemiological reappraisal of the familial aggregation of prostate cancer: A meta-analysis’, PLoS ONE, 6(10). doi: 10.1371/journal.pone.0027130.
Kristal, A. R. et al. (2011) ‘Serum Lycopene Concentration and Prostate Cancer Risk : Result from the Prostate Cancer Prevention Trial’, American Association of Cancer Research (AACR).
Mazhar, D. and Waxman, J. (2002) ‘Prostate cancer’, Postgraduate Medical Journal. Postgrad Med J, pp. 590–595. doi: 10.1136/pmj.78.924.590.
Novaldy, R. and Iyos, R. N. (2016) 'Influence of Tomatoes ( Solanum lycopersicum ) in Prostate Carcinoma Risk Reduction', Majority, 5(5), pp. 9–13.
Rawla, P. (2019) ‘Epidemiology of Prostate Cancer’, Medecine Nucleaire, 10(2), pp. 63–69. doi: 10.1016/j.mednuc.2007.11.003.
Roh, M. K. et al. (2013) ‘A simple method for the isolation of lycopene from Lycopersicon esculentum’, Botanical Sciences, 91(2), pp. 187–192. doi: 10.17129/botsci.413.
Soares, N. D. C. P. et al. (2019) ‘Comparative analysis of lycopene content from different tomato-based food products on the cellular activity of prostate cancer cell lines’, Foods, 8(6). doi: 10.3390/foods8060201.
Tambunan, Nicholas & Umbas, R. (2015) 'The Role of Nutritional Factors in Prostate Cancer Prevention', Indonesian Journal of Cancer,8(3), pp. 135–140. Available at: httpwww.indonesianjournalofcancer.or.ide-journalindex.phpijocarticleview381.
Wang, Y. et al. (2016) ‘Lycopene, tomato products and prostate cancer-specific mortality among men diagnosed with nonmetastatic prostate cancer in the Cancer Prevention Study II Nutrition Cohort’, International Journal of Cancer, 138(12), pp. 2846–2855. doi: 10.1002/ijc.30027.
Widayati, P. et al. (2013) 'Preparation of Reagents Kit Immunoradiometrlcassay Free Prostate Specific Antigen For Prostate Cancer Detection', Indonesian Journal of Applied Chemistry,15(2), pp. 14–24. doi: 10.14203/jkti.v15i2.107.
How to Cite
P, Ardhiana et al. UTILIZATION OF TOMATOES (SOLANUM LYCOPERSICUM L.) TO REDUCE THE RISK OF PROSTATE CANCER: A SYSTEMATIC REVIEW. International Journal of Biomedical Nursing Review, [S.l.], v. 1, n. 1, p. 32-42, aug. 2022. Available at: <http://jos.unsoed.ac.id/index.php/ijbnr/article/view/6532>. Date accessed: 23 mar. 2023. doi: https://doi.org/10.20884/1.ijbnr.2022.1.1.6532.