Aspirin Stability Comparation In Hydrochloric Acid and In Phosphate Buffer As Critical Parameter At Dissolution Medium Choices

  • Rehana R
  • Ade Martinus

Abstract

Aspirin tend to be hydrolyzed as salisilic acid and acetic acid, so that aspirin stability at hydrochloric acid and phosphate buffer is critical parameter in dissolution medium choice. The objective of this research was to compare aspirin stability in HCl 0.1N and phosphate buffer pH 7.4.This research was experimental laboratory research include analysed of aspirin decreased every hour during 6 hours solubilized in HCl 0.1N and phosphate buffer pH 7.4 using spectrophotometry method, calculated time that aspirin 10% hidrolized (t10%) in both mediums, and compared t10% aspirin HCl 0.1N and phosphate buffer pH 7.4.The result showed aspirin more stable (p = 0.003) in phosphate buffer pH 7.4 (t10% = 445 minutes) than in HCl 0.1N (t10% = 389 minutes)

Published
2018-02-12
How to Cite
R, Rehana; MARTINUS, Ade. Aspirin Stability Comparation In Hydrochloric Acid and In Phosphate Buffer As Critical Parameter At Dissolution Medium Choices. Acta Pharmaciae Indonesia, [S.l.], v. 4, n. 01, p. 43-48, feb. 2018. ISSN 2337-8433. Available at: <http://jos.unsoed.ac.id/index.php/api/article/view/563>. Date accessed: 25 apr. 2018.