The Effect of Propylene glycol, Oleic Acid amd Isopropilalcohol To The Transdermal Patch Losartan Potassium Formula

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Nuryanti Nuryanti Kharis Nugroho Ronny Martien

Abstract

Losartan is the potent antihypertension which has low oral bioavailability and short elimination half-life. This research was aimed to determine the optimum formula composition, characteristics and profile of transport in vitro transdermal patch losartanpotassium. Design formulation was based on simplex lattice design method using Design Expert. The evaluations included visual appearance patch, weight and thickness, moisture uptake, loss on drying, folding endurance, and drug content. In vitro transport studies of losartan was evaluated in a vertical diffusion cells system. The assay of losartan was
performed using HPLC method and analyzed by WinSAAM. The composition of the transdermal patch losartan of optimum formula was 44.4% propylene glycol, 29.3% oleic acid, and 26.3% isopropyl alcohol, with the characteristics thickness of 0.6 mm, weighs 82.2 mg, loss on drying 12.8%, moisture uptake 6.4%, folding endurance of 300 and drug contents 98.9% . Profie of transport in vitro losartan resulted in a five-compartment models with first-order kinetics

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How to Cite
NURYANTI, Nuryanti; NUGROHO, Kharis; MARTIEN, Ronny. The Effect of Propylene glycol, Oleic Acid amd Isopropilalcohol To The Transdermal Patch Losartan Potassium Formula. Acta Pharmaciae Indonesia, [S.l.], v. 4, n. 01, p. 7-14, feb. 2018. ISSN 2337-8433. Available at: <http://jos.unsoed.ac.id/index.php/api/article/view/559>. Date accessed: 24 feb. 2018.
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